Project Grant R01NS146463
- The National Institute of Neurological Disorders and Stroke awarded Drexel University $363,464 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on September 25, 2924, for research into medial deep dorsal glycinergic interneurons as a therapeutic target to improve locomotion following spinal cord injury. The research examines inhibitory interneurons in the spinal cord's dorsal horn that regulate proprioceptive sensory input to...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $639,875 on August 10, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing Project Grant R01NS151292). The recipient will characterize the molecular steps that allow post-mitotic neurons to correctly integrate into neural circuits, focusing on motor neurons that target adult leg muscles in...
- The National Institute of Neurological Disorders and Stroke awarded The Johns Hopkins University $232,938 on February 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to generate critical knowledge on neuronal membrane proteasome-derived peptide signaling in the peripheral nervous system. The research extends prior work on NMP-peptides and their role in peripheral neuron crosstalk and regulation. The award funds proteomics,...
- The National Institute of Neurological Disorders and Stroke awarded Texas A&M University $500,307 on April 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate cross-neuronal structural plasticity in Drosophila motor circuits. The research addresses how different neuron and synapse types undergo structural rewiring in response to neural injury, with focus on how premotor neurons, motor neurons, and muscles in...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Temple University $237,750 on April 8, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate a genetic method for selectively lesioning axons or pruning axonal terminals. The research addresses motor control mechanisms by engineering a novel chimeric protein...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of the University of Pennsylvania $100,228 on September 30, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct optical interrogation of neural mechanisms mediating force production. The recipient will employ in vivo two-photon calcium imaging to record motor neuron activity and proprioceptive inputs in mice during licking and...
- The National Institute of Neurological Disorders and Stroke awarded Duke University $100,228 on December 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, assistance type: Project Grant F31NS149497). The project investigates cell-type-specific contributions of the primary somatosensory cortex to skilled forelimb control using two-photon calcium microscopy, optogenetic perturbation, genetic access to projection neuron types...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Princeton University $132,813 on April 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing 93.853) to characterize multimodal processing with whole-brain approaches in Drosophila. The research employs whole-brain functional imaging in behaving animals, connectome-constrained computational models, and a range of modern...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Thomas Jefferson University (operating as Sidney Kimmel Medical College) $509,949 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research on the molecular and cellular mechanisms of synaptic growth restriction in central olfactory circuits. The...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Wake Forest University $533,623 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating mechanisms that protect neurons from glutamate excitotoxicity during metabolic stress. The research uses avian neurons, which naturally resist...
The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services, awarded Drexel University $547,255 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of the functional organization of descending neuron networks that control collision-avoidance behavior. Using electron microscopy connectomes of the central nervous system at synaptic resolution, the research examines how descending pathways coordinate motor programs and transform visual information of an approaching object into motor commands. The work combines computational modeling and whole-cell electrophysiology with genetic manipulations to predict, measure, and perturb information propagation across descending pathways, with focus on embedded hierarchical network structures that enable differential motor-program recruitment and flexible behavioral responses. Work is performed in Philadelphia, Pennsylvania, with a period of performance from September 1, 2026, through June 30, 2031. The award is structured as a Project Grant, a standard assistance type for extramural research supporting basic investigation of fundamental brain and nervous system structure and function.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $547.3k | 8/27/26 |