Project Grant R01NS146234
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $460,625 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate time-dependent membrane proteomics in circadian pacemaker neurons. The recipient will use cutting-edge proteomic approaches combined with biotin proximity labeling to survey the membrane proteome of circadian neurons during the...
- The National Institute of Neurological Disorders and Stroke awarded the Trustees of Boston University $170,132 under Project Grant F31NS145737 on December 1, 2025, to support research on the regulation of cerebral blood flow by intrinsic neuromodulation across wakefulness and sleep states. The award is made under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research will examine neurovascular coupling through two coordinated aims....
- The National Institute of Neurological Disorders and Stroke awarded $235,500 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support single-cell morphological dissection of brain endothelial cells. The award funds research investigating cerebrovascular integrity at the single-cell level, with focus on endothelial cell...
- The National Institute of Neurological Disorders and Stroke awarded The Ohio State University $630,925 on May 1, 2026, to investigate circadian clock physiology in cortico-limbic brain circuits and its role in regulating complex behavioral states including mood, memory, and executive function. The research examines how transcriptional timing feedback loops and clock oscillators outside the suprachiasmatic nucleus operate at cellular and systems levels within cortico-limbic circuits, and how...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $430,375 on June 22, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop x-ray dark-field imaging technology for carotid hemodynamic analysis using anisotropic iron oxide nanorods as contrast agents. The research addresses cerebrovascular disease assessment and plaque vulnerability prediction by advancing grating-based interferometric...
- The National Institute of Neurological Disorders and Stroke awarded Boston Children's Hospital $489,500 on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate cerebrospinal fluid neurotransmitter-based regulation of the choroid plexus blood-brain barrier. The research examines how excessive cerebrospinal fluid glutamate impairs choroid plexus barrier integrity through the metabotropic glutamate receptor 8...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $575,485 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of the BCL11A gene in neuron function and neurological disease. The award funds research examining how BCL11A, a zinc-finger transcription factor, contributes to intellectual disability, autism spectrum disorder, epilepsy, schizophrenia, and...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, San Diego $121,554 on February 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of tanycyte barriers at circumventricular organs in health and neuroinflammation. The project, titled "Investigating the Role of Tanycyte Barriers at the Circumventricular Organs in Health and Neuroinflammation," will...
- The National Institute of Neurological Disorders and Stroke awarded Boston Children's Hospital $711,952 under Project Grant R01NS144151 on May 2, 2026, to investigate circadian regulation of synaptic function and sleep-wake behavior. The research examines how circadian rhythms regulate synaptic function to modulate behavior with time of day, focusing on the molecular mechanisms by which the transcription factor BMAL1 and its phosphorylation at serine 42 orchestrate synaptic vesicle dynamics,...
- The National Institute of Neurological Disorders and Stroke awarded the University of Rochester $1,606,088 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate spatiotemporal control of cerebral blood flow by purinergic signaling networks. The project examines neurovascular coupling—the process by which cerebral blood flow rapidly directs to active brain regions to meet metabolic demands—with specific focus...
The National Institute of Neurological Disorders and Stroke awarded Emory University $457,272 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate circadian rhythm regulation of the blood-brain barrier. The project examines how pericytes—mural cells in close contact with brain capillaries—strengthen circadian rhythms in brain endothelial cells, with a focus on the role of caveolin-1 (CAV1), a protein involved in vesicular trafficking and membrane signaling. The research aims to determine how pericyte contact regulates endothelial CAV1 expression, define CAV1's role in regulating brain endothelial circadian rhythms, and elucidate how CAV1 affects the blood-brain barrier's circadian rhythms in vivo while evaluating rescue strategies. The findings are intended to identify potential therapeutic approaches for restoring blood-brain barrier rhythmicity in diseases associated with blood-brain barrier dysfunction. Performance will occur in Atlanta, Georgia, with a period of performance from September 1, 2026, through August 31, 2031. The funding is classified as a Project Grant, a standard assistance type under NINDS's extramural research portfolio supporting basic research into the structure and function of the brain and nervous system.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $457.3k | 8/14/26 |