Project Grant R01NS144311
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the development of genetic testing and counseling for Pantothenate Kinase-Associated Neurodegeneration (PKAN) in the Dominican Republic. The $347,767 award, with a performance period from August 20, 2025 to August 19, 2027, aims to establish a process for genetic...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop a novel gene therapy approach to reduce neurotoxicity in Parkinson's disease. The $1,009,212 award to the Van Andel Research Institute in Grand Rapids, MI will fund pharmacodynamic, pharmacokinetic, and in vivo efficacy studies to enhance the activity of the...
- This federal Project Grant award of $525,436.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research on the structural pharmacology of GIRK channel disease mutants. The research aims to elucidate the molecular mechanisms underlying the loss of potassium selectivity and constitutive activation of GIRK2 channels associated with Keppen-Lubinsky syndrome, a...
- This $1,002,148 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research on the role of autophagy, a cellular process for clearing damaged organelles and inclusions, in neurodegeneration. The research aims to determine how levels of the lipid phosphatidylinositol 3-phosphate (PI(3)P) regulate autophagy in neurons, including...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research by Eikonizo Therapeutics, Inc. to develop next-generation histone deacetylase 6 (HDAC6) inhibitors for the treatment of Parkinson's disease. The $499,766 award, active from August 1, 2025 to July 31, 2026, aims to evaluate the efficacy of Eikonizo's development candidate...
- This Project Grant award, totaling $101,668.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research to investigate the role of the PANX1 ion channel in cortical development and its potential contribution to the pathogenesis of polymicrogyria, a malformation of the cerebral cortex. Key objectives include...
- This Project Grant award, valued at $232,524, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award will support research at Stony Brook University to investigate the role of the AMPK signaling pathway in regulating energy production and usage during the myelination process in oligodendroglial cells. The goal is to better understand...
- This $475,475 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, Massachusetts. The goal of the award is to evaluate a small molecule inhibitor of the USP30 enzyme as a potential neuroprotective therapy for Parkinson's disease. The research will assess...
- This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), supports research to understand the molecular mechanisms underlying BK potassium channel dysfunction in neurological disorders. The $655,968 grant, awarded on April 21, 2025, will be used by researchers at Washington University to conduct a multi-year study investigating how...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $676,388 to St. Jude Children's Research Hospital Inc. to conduct research on how polarity signals coordinate neuronal differentiation and nuclear organization. The key aims of the research are to define how the proteins SIAH2 and PARD6A regulate chromatin compaction and nuclear...
This Project Grant award for $735,373, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to advance the development of pantothenate kinase (PANK) activators as a potential therapy for pantothenate kinase-associated neurodegeneration (PKAN). The award will fund the development of the next generation of PANK activators to overcome the pharmacokinetic limitations of the previous clinical candidate BBP-671, with the goal of advancing a new candidate toward clinical trials. The research is being conducted by St. Jude Children's Research Hospital Inc., a renowned pediatric treatment and research facility, over the period from September 1, 2025 to May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $735.4k | 8/21/25 |