Project Grant R01NS143998
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $430,170 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Pittsburgh. This grant supports research to identify genetic determinants of the neuropathogenesis of enterovirus D68 (EV-D68) using a novel human spinal cord organoid (HSCO) model. The overarching goal is to better understand how recent strains of EV-D68 can cause paralysis, known as acute flaccid...
- This $217,976 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is for a study to develop an immunocompetent ferret model to investigate the spinal pathology associated with Enterovirus D68 (EV-D68) infection. The study has two main objectives: 1) to examine the longitudinal course of spinal damage in the ferret model, and 2) to delineate the role of spinal cord glial cells in...
- This $457,778 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports the development of a human microphysiological system (MPS) to investigate the peripheral nervous system (PNS) neurotropism of respiratory syncytial virus (RSV) and SARS-CoV-2. The research aims to elucidate the underlying mechanisms contributing to chronic neurological impairments associated with RSV and...
- This Project Grant award of $426,313, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), supports research at The Johns Hopkins University to investigate the signaling pathways that disrupt neurofilament (NF) phosphorylation dynamics and lead to NF hyperphosphorylation, a pathology associated with neurodegenerative diseases such as amyotrophic lateral...
- This Project Grant award for $158,324.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), supports research to investigate the mechanisms underlying seizures during acute viral infection and the development of chronic epilepsy in a mouse model of viral-induced temporal lobe epilepsy. The key products and services to be delivered include: quantifying...
- This federal Project Grant award of $601,307 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to elucidate the mechanism by which HIV-1 downregulates specific RNA modifications (YW, DPH, and M1ACP3Ps) that normally repress ribosomal frameshifting on HIV-1 mRNA. The research aims to determine how this deregulation of RNA...
- This federal Project Grant award of $761,591 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is funding research to characterize the firing patterns of spinal neurons during motor behaviors in mice. The goal is to better understand how the spinal cord processes motor commands for limb movements. The award to the Salk Institute for Biological Studies in La Jolla, CA...
- This federal Project Grant award, ID R35NS137247, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award totaling $1,174,913.00 supports research to understand the fundamental mechanisms of homeostatic plasticity, a compensatory process that stabilizes neural function, and its potential links to neurodevelopmental disorders such as autism and...
- This $2,503,949 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Rockefeller University aimed at discovering therapeutic targets for neurological diseases. The project utilizes new techniques and concepts to study the fundamental mechanisms of brain disorders, focusing on how differences in cell-specific RNA regulation contribute to...
- This Project Grant award of $532,381 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research into the pathogenic mechanisms of the KIF5A gene mutation associated with amyotrophic lateral sclerosis (ALS). The key objectives of this 5-year research project are to: 1) determine the gain-of-function effects of the ALS-associated KIF5A exon 27 skipping variant...
This federal Project Grant award of $411,446 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the mechanisms underlying motor neuron toxicity in Acute Flaccid Myelitis (AFM), a debilitating polio-like paralytic illness in children caused by enterovirus infection. The research aims to: 1) Identify viral factors that cause differential motor neuron toxicity between enterovirus D68 and enterovirus A71; 2) Determine the extent and potential repair of persistent nuclear pore complex dysfunction in motor neurons after enterovirus D68 infection; and 3) Define the role of Wallerian degeneration in enterovirus D68-induced motor neuron dysfunction and death. This work will leverage the observation that enterovirus A71 infection leads to a spontaneously reversible form of AFM, while enterovirus D68 causes permanent paralysis. The project will be conducted by the Hugo W. Moser Research Institute at Kennedy Krieger, Inc., a non-profit medical research organization in Baltimore, Maryland, over the award period from August 1, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $411.4k | 7/28/25 |