Project Grant R21AI190739

Award Date 2/1/25
Completion Date 1/31/27
Dollars Obligated $218K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Maryland, USA

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $217,976.00 to The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. (HJF) to conduct research on enterovirus D68 (EV-D68) and its potential to cause acute flaccid myelitis (AFM), a polio-like paralysis, in children.

The key objectives of this 2-year research project are to: 1) Examine the course of spinal damage longitudinally in a ferret model infected with neurotropic EV-D68 isolates, and 2) Delineate the role of spinal cord glial cells in driving spinal pathology after EV-D68 infection. This research aims to provide novel insights into the spinal damage observed during AFM following EV-D68 infection, which is a growing public health concern. The award term runs from February 1, 2025, to January 31, 2027.

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