Project Grant R01NS143904
- Federal Project Grant Award Summary The University of Pittsburgh received a $571,404 Project Grant awarded May 30, 2025, by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The research project, titled "Adipokines as Novel Therapy to Promote Functional Recovery After Experimental Traumatic Brain Injury," will extend through April 30, 2030. This award funds...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $453,860 to Henry Ford Health + Michigan State University Health Sciences on June 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This project grant funds preclinical research investigating the metabolic regulation of neutrophil extracellular traps (NETs) in traumatic brain injury (TBI). The research will examine...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $654,218 Project Grant to the University of Maryland, Baltimore on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The five-year research initiative, scheduled for completion on July 31, 2030, investigates the mechanisms and intervention strategies of cyclic GMP-AMP synthase (cGAS) signaling in brain trauma-induced...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $262,500 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award, effective April 1, 2026 through March 31, 2028, supports research to develop a novel predictive tool for identifying traumatic brain injury (TBI) patients with capacity to recover...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Johns Hopkins University a $521,963 Project Grant effective August 1, 2025, through June 30, 2030, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative investigates the role of gut serotonergic signaling in traumatic brain injury (TBI) pathogenesis, addressing a significant gap in understanding the...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Ohio State University a Project Grant totaling $202,599 on September 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative investigates the role of NFκB (nuclear factor kappa-light-chain-enhancer of activated B cells) in chronic inflammation, microglia priming, and neuropsychiatric...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant totaling $453,970 to the Hugo W. Moser Research Institute at Kennedy Krieger, Inc. under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award, effective June 1, 2025 through May 31, 2027, funds research investigating the therapeutic effects of intranasal heparin-binding epidermal growth factor (HB-EGF)...
- This $309,279 Project Grant award, funded by the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) program, supports a research study on traumatic brain injury (TBI) and psychological health conducted by Florida State University. The primary objectives are to adapt the Ohio State University TBI Identification Method and the STAIR-NT intervention for first responders with TBI, analyze the data, and disseminate the study findings. Key sub-award activities...
- Federal Project Grant Award Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded Trustees of Boston University a $166,752 Project Grant effective April 15, 2026, through March 31, 2031, under the Child Health and Human Development Extramural Research program (CFDA 93.865). This five-year research career development program will deliver evidence-based self-management training interventions and implementation science research focused on...
The University of South Florida received a $568,920 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded April 17, 2026, with completion targeted for March 31, 2031. The grant funds research investigating how traumatic brain injury (TBI)-induced dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis affects neuroplasticity and the long-term efficacy of circuit-directed rehabilitation, with particular focus on sex-dependent differences in outcomes. The research addresses a significant public health need, as TBI affects over 2.87 million people annually, with approximately 50% experiencing chronic psychological health conditions including sensory, cognitive, and sleep deficits. The research deliverables include establishing a comprehensive profile of sex-dependent HPA axis dysregulation and neuroplasticity outcomes between 1 to 3 months post-injury, and quantifying the short-term efficacy of circuit-directed rehabilitation administered during various HPA axis dysfunction periods. The investigation utilizes a midline fluid percussion injury model in male and female Sprague-Dawley rats to test the hypothesis that TBI causes sex-dependent HPA axis fluctuations resulting in temporal shifts in circulating corticosterone and brain glucocorticoid receptor levels. Research findings are expected to enhance understanding of rehabilitation efficacy mechanisms and inform improved therapeutic approaches for TBI recovery across sexes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $568.9k | 4/17/26 |