This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research to evaluate the therapeutic potential of hypoxia mimetics in treating inflammatory demyelinating disease, particularly multiple sclerosis (MS). The $1,949,990 award, running from August 1, 2024 to June 30, 2029, will support research to: 1) define an optimal...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program, supports research on the role of antibodies in the pathogenesis of multiple sclerosis (MS). The $405,282 award will fund a 5-year study to: Screen biobanked serum and cerebrospinal fluid (CSF) samples from MS patients, clinically isolated syndrome (CIS) patients, and...
This $742,352 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program is funding a collaborative research project to study the impact of childhood adversity on health outcomes for individuals with multiple sclerosis (MS), particularly among high-risk minority populations. The award supports the development of culturally-sensitive research...
The federal Project Grant award R21NS136961, totaling $241,500.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research conducted by the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to investigate discrete neurodegenerative changes in the spinal cord of people with multiple sclerosis using 7...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $654,287 to the Icahn School of Medicine at Mount Sinai to develop a computational model of neurocognitive impairment in multiple sclerosis (MS). The goal is to provide a psychometrically valid and biologically informed update to the understanding of cognitive status in...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,500,600 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Rector & Visitors of the University of Virginia (University of Virginia) to investigate the role of specific genes, including TMEM125B and JAMS 2 & 3, in central nervous system (CNS) myelination. The research aims to: 1) determine the role of TMEM125B in CNS myelination, 2)...
This federal Project Grant award of $694,369 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program supports a multi-scale, multi-modal, longitudinal imaging study to examine the association of cognitive function with changes in brain function, anatomy, and neuronal integrity in patients with multiple sclerosis (MS). The study aims to utilize advanced MRI...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $168,455.00 to New York University School of Medicine to investigate the role of region-specific reactive astrocyte factors in neuroinflammation. The project aims to characterize the functional effects of astrocyte-derived hepatocyte growth factor (HGF) and...
This $230,580 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to understand the mechanisms underlying brain-immune interactions at the blood-brain barrier. The overarching goal is to generate novel targets for immunotherapy in neuroinflammatory conditions. The research involves genetic manipulation of the brain...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $158,260 to the University of Virginia to investigate the role of enteric glial cells in the pathogenesis of multiple sclerosis (MS) using the experimental autoimmune encephalomyelitis (EAE) model. The research aims to characterize T cell responses against enteric glial cells, which express myelin proteins, and...