Project Grant R01NS142873
- The National Institute of Neurological Disorders and Stroke awarded The Leland Stanford Junior University $154,274 on May 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop small-focus transparent transducers for transcranial ultrasound stimulation in mice. The research addresses the absence of noninvasive tools for focal brain-wide neuromodulation, a limitation that constrains circuit-based understanding of neural...
- The National Institute of Neurological Disorders and Stroke awarded The Leland Stanford Junior University $499,516 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (NINDS, CFDA 93.853) to develop a novel imaging strategy for optimizing brain tumor immunotherapy. The recipient will develop a first-in-class small molecule positron emission tomography (PET) probe capable of crossing the blood-brain barrier and binding to perforin, a...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the Department of Health and Human Services National Institutes of Health, awarded $460,349 to The Leland Stanford Junior University on May 8, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) for research on programmable therapeutic macromolecule delivery via engineered trogocytosis. The research develops TRANSFER (Trogocytosis-Based...
- The National Institute of Neurological Disorders and Stroke awarded The Leland Stanford Junior University $209,177 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the MAP4K4 pathway as a target for inhibiting pediatric high-grade glioma invasion. The research comprises three coordinated aims. Aim 1 uses high-throughput methylation and genomic sequencing to test for variants of MAP4K4 and associated...
- The National Institute of Biomedical Imaging and Bioengineering awarded University of California, Berkeley $120,394 on May 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop genome editing delivery vehicles that amplify editing efficiency by enabling cells to produce and distribute CRISPR-Cas9 editing enzymes to neighboring cells in vesicles. The research addresses inefficient delivery of genome editing to cell...
- The National Institute of Neurological Disorders and Stroke awarded The Leland Stanford Junior University $522,632 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of pseudouridine synthase PUS7 in neurodevelopment. The recipient will use two-dimensional and three-dimensional in vitro neuronal differentiation systems, primary tissues and cells, cutting-edge sequencing tools for RNA modification...
- The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of California, San Francisco $2,656,684 on February 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to discover and validate gene therapy and biologic delivery vectors for central nervous system diseases using physiologically maintained deceased human cadavers as a discovery platform. The award funds development of an...
- The National Institute on Aging awarded The Regents of the University of California, San Francisco $1,491,257 on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop and optimize CRISPR/Cas9 genome editing as a therapeutic strategy for frontotemporal dementia caused by MAPT mutations (FTD-tau). The recipient will execute three research aims over a five-year period of performance concluding December 31, 2030, at locations in California. Aim 1 identifies guide RNA pairs that...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $122,526 on May 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Project Grant K99NS149164). Stanford will use the funding to delineate Alzheimer's disease initiation and propagation using novel adult human brain organoids. The work employs...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $1,733,072 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a multi-resolution open-top light-sheet expansion microscopy system. The project will advance 3D microscopy for high-throughput imaging of expanded tissues with ultra-high resolution—sub-150 nanometer...
The National Institute of Neurological Disorders and Stroke awarded The Leland Stanford Junior University $618,680 on August 11, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop ultrasound-controlled in vivo gene editing with photoswitchable CRISPR-CasMini technology. The project aims to enable noninvasive, cell-type-specific gene editing in the brain by combining two engineering innovations: a single-chain photoswitchable CasMini protein packaged in blood-brain-barrier-crossing adeno-associated virus vectors, and mechanoluminescent nanotransducers that produce light when stimulated with focused ultrasound deep within tissue. This approach addresses current limitations in photocontrolled CRISPR systems—their size prevents packaging in AAV, and existing light-delivery methods into the brain are invasive and tissue-damaging. The specific aims include optimizing light-induced CasMini efficacy and specificity, optimizing ultrasound-activated light sources for gene editing, and demonstrating noninvasive localized inactivation of an endogenous gene targeted by anti-epileptic treatments. The work represents collaboration between two groups with complementary expertise in photoregulatable protein engineering for brain expression and light-sound-interactive materials engineering. Performance occurs in Palo Alto, California, with a period of performance through June 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $618.7k | 8/10/26 |