Project Grant R01NS142383

Award Date 7/15/25
Completion Date 6/30/30
Dollars Obligated $594K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Utah, USA
Similar Awards
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA Program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, is focused on developing a noninvasive, nanoparticle-directed therapy to deliver treatments to the peripheral nervous system. The $310,834 award to Clemson University supports research to design and implement a nerve-targeting polymersome platform that can penetrate the blood-nerve barrier and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $296,151 to Insoma Bio, Inc. to investigate the use of their proprietary Fractomer biomaterial to improve outcomes after peripheral nerve repair. The project aims to demonstrate that Fractomer, an injectable polypeptide scaffold, can provide the necessary mechanical support and...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $5,666,172 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to New York University (NYU) to conduct research on targeting Schwann cell dysfunction and repair signaling in chemotherapy-induced painful peripheral neuropathy (CIPPN). The research aims to study the role of the peroxisome proliferator activated receptor gamma (PPARG) and low-density lipoprotein receptor related protein 1 (LRP1)...
This $999,998 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports the development of Renerva LLC's Peripheral Nerve Matrix (PNM) technology. PNM is a tissue-based hydrogel derived from porcine nerve that aims to improve functional outcomes for patients with challenging peripheral nerve gap injuries. The Phase I project will optimize the PNM...
This $210,600 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research to investigate how Wnt signaling mediates the formation of repair cells from Schwann cells in the peripheral nervous system. The primary goals are to 1) provide functional tests of the role of Wnt receptors and ligands in controlling repair cell...
This $536,617 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the mechanisms of neural regeneration in model organisms. The primary awardee, Oregon Health & Science University, will conduct experiments using planarians and zebrafish to investigate how adult neural stem cells can regenerate neural tissue and restore...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders provides $499,979 to The Salk Institute for Biological Studies to conduct research on the role of astrocytes in neuropathic pain. The key objectives are to: 1) determine how peripheral nerve injury alters dorsal horn astrocyte function, 2) elucidate how targeted interventions control dorsal horn...
Renerva LLC, a for-profit manufacturer, is developing peripheral nerve matrix (PNM) technologies to facilitate functional recovery in animal models of direct muscle neurotization (DMN) through a $494,955 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The two-year project aims to 1) optimize the formulation of a clinical-grade PNM product to provide...
The University of Nebraska Medical Center (UNMC) was awarded a $437,331 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will support the development of a novel "optoelectronically active nerve adhesive" to accelerate peripheral nerve repair and regeneration. Specifically, the project aims to incorporate innovative...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on developing a novel drug candidate to treat demyelinating neuropathies. The $352,073 award will support rigorous in vivo testing of the experimental ABCA1 agonist drug, CS6253, in validated mouse models of hereditary peripheral nerve disorders characterized by impaired...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders", provides $594,115.00 to the University of Utah to conduct research on the pathophysiology of peripheral nerve regeneration and the formation of neuromas.

The key objectives of this 5-year project are to: 1) analyze the cellular composition, activation states, and spatial niches involved in neuroma formation after severe nerve injuries; 2) evaluate the role of neutrophil extracellular traps (NETs) in impairing nerve regeneration and promoting neuroma development; and 3) investigate the use of DNase I as a potential treatment to improve axonal regeneration after severe nerve injuries. The research aims to address knowledge gaps in the mechanisms underlying neuroma formation and determine how NETs impact nerve regeneration, providing essential data to design future human trials of DNase I for treating nerve injuries.

Generated 8/5/25, 3:11 AM