Project Grant R01NS141861
- This federal Project Grant award for $659,325.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to understand the role of mutant IDH1 in glioma pathophysiology and immune response mechanisms. The research will use a novel murine glioma model developed by incorporating genetic lesions into neural progenitor cells using the...
- This Project Grant award of $687,279 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to uncover the effects of standard-of-care therapy on immune and neoplastic cell population dynamics in pre-clinical mouse models of glioblastoma (GBM) and analysis of human GBM samples. The goal is to identify tumor microenvironment areas of therapeutic...
- This federal Project Grant award of $225,599, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research on the contributions of sex chromosomes versus gonadal hormones in shaping sex differences in epilepsy. The University of Illinois, the awardee, will utilize in vivo video-electroencephalography, RNA sequencing, and immunostaining to determine...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $472,124 to Beth Israel Deaconess Medical Center, Inc. to conduct exploratory studies on the role of TREM1 and TREM2 receptors in the immune response to glioblastoma, an aggressive form of brain cancer. The research aims to use a novel mouse model of glioblastoma to investigate how...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $226,112 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Colorado-Denver. The grant is focused on leveraging sex differences to understand the brain's macrophage immune response to perinatal hypoxic ischemic encephalopathy (HIE), a leading cause of death and disability in newborns. The research aims to determine the primary...
- This federal Project Grant award of $517,494.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Duquesne University to define differentially expressed RNA splice isoforms of the transcription factor ATF3 that are responsible for sex-specific differences in pain and pain-relief. The research aims to provide a more comprehensive...
- This Project Grant award of $444,125.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of progesterone receptors in regulating the transition from episodic to chronic migraine. The researchers at the University of Virginia will use mouse models to measure pain responses and neuronal activity during experimentally-induced migraine...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $168,455 to New York University School of Medicine to investigate region-specific factors in reactive astrocytes during neuroinflammation. The research project aims to explore the heterogeneous responses of astrocytes, the most abundant brain glial cells, to inflammation, focusing on...
- This federal Project Grant award of $460,940 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research conducted by the University of Texas MD Anderson Cancer Center to investigate how genetic risk factors for glioma, a type of brain cancer, impact neurodevelopmental processes and potentially promote tumor formation. The research leverages human...
- This federal Project Grant award of $131,360 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding research at the University of New Haven to characterize the long non-coding RNA GIHCG and assess its potential as a therapeutic target for glioblastoma, the most aggressive form of brain cancer. The 4-year project aims to use CRISPR/Cas9 gene editing to...
This federal Project Grant award of $414,953 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is focused on understanding the role of inflammasomes, which are protein complexes that induce inflammatory responses, in driving sexual dimorphism in glioma therapies. The key objectives are to determine whether inhibiting the NLRP3 inflammasome can overcome inflammation-induced immune suppression and potentiate antitumor immune therapies for malignant gliomas, particularly in female patients. The award supports research at Duke University from August 1, 2025 to April 30, 2030 to explore the links between NLRP3, sex hormones, and immune regulation in glioma progression and treatment response.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $415.0k | 7/31/25 |