This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the anatomical plasticity and functional impact of specific spinal cord interneurons, known as long-ascending propriospinal neurons (LAPNs), in the context of spinal cord injury. The $462,296 award, with a project period from June 2025 to May 2030, will enable the University of Louisville to study LAPN dendritic and axonal anatomy before and after various spinal cord injuries in adult rats. The research will also examine the interactions between reticulospinal axons and LAPNs, and the impact of silencing LAPNs on functional recovery following different types of spinal cord injuries. Advanced imaging techniques and machine learning-aided locomotor analysis will be utilized. The findings are expected to provide insights into the adaptive and maladaptive roles of LAPN plasticity, with potential translational applications for cell, drug, and neuromodulation therapies to improve outcomes for individuals with spinal cord injuries.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $462.3k | 6/2/25 |