This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $532,381 to Emory University to conduct research on the pathogenic mechanisms of KIF5A-associated Amyotrophic Lateral Sclerosis (ALS). The key research objectives are to: 1) determine the gain-of-function effects of the ALS-associated KIF5AΔE27 variant in transgenic mouse models...
This Project Grant award of $374,349 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the development and optimization of a new animal model for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The goal is to create a mouse model that accurately recapitulates the human disease spectrum by incorporating an acetylation-mimicking...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to develop a novel cellular model for investigating amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will directly convert patient-derived fibroblasts into neurons, preserving the epigenetic age of the starting cells, in order to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This federal Project Grant award, valued at $129,717.00 and awarded on January 20, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of neutrophil heterogeneity and molecular mechanisms in driving amyotrophic lateral sclerosis (ALS). The research aims to identify subpopulations of neutrophils and associated mechanisms...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $227,205 to Cedars-Sinai Medical Center to conduct research aimed at identifying pathological signatures and molecular markers in the motor cortex of patients with amyotrophic lateral sclerosis (ALS). The key research objectives are to: 1) use advanced MRI techniques to...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $121,554 to the University of California, San Diego (UCSD) to investigate the role of RNA processing misregulation in amyotrophic lateral sclerosis (ALS). The research aims to: (1) examine the impact of ALS-related mutations in the KIF5A gene on the proteotoxic pathway, (2) explore...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to investigate the role of proton-mediated signaling at the neuromuscular junction in amyotrophic lateral sclerosis (ALS) models. The $387,525 award to the Board of Regents of the Nevada System of Higher Education, operating through the University of Nevada, Reno, will...
This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), aims to develop advanced base and prime editing strategies to correct common ALS-causing mutations in the SOD1 gene. The $124,246 award, granted to the University of Massachusetts Medical School, will support in vitro and in vivo studies to create next-generation base and prime editors for...
This federal Project Grant award of $2,307,075, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, supports an ambitious research program at Stanford University focused on defining novel mechanisms of human neurodegenerative diseases and translating those findings into new therapeutic strategies. The key objectives of this grant include: 1) Conducting genome-wide...