Project Grant R01NS140701
- This $365,000 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under its Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the development of novel cellular systems for modeling DYT1 dystonia using patient-derived neurons. The key objective is to investigate the molecular pathogenesis of DYT1 dystonia, a severe hereditary movement disorder, by examining how dysregulation of the nuclear...
- This federal Project Grant award, valued at $643,377.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to investigate cellular mechanisms of enteric nervous system damage in CLN2 disease, a rare neurodegenerative lysosomal storage disorder. The research aims to better understand how lysosomal dysfunction leads to...
- This federal Project Grant award of $140,690 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to investigate the relationship between gamma oscillations in the motor network and dyskinesia (excessive movement) in Parkinson's disease patients. The goals are to use chronically implanted neurostimulators and wearable sensors...
- This federal Project Grant award, ID R35NS137247, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award totaling $1,174,913.00 supports research to understand the fundamental mechanisms of homeostatic plasticity, a compensatory process that stabilizes neural function, and its potential links to neurodevelopmental disorders such as autism and...
- This federal Project Grant award of $340,822 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research by Drexel University to investigate the role of inhibitory interneurons in the dorsal horn of the spinal cord as a potential target for improving locomotor function following spinal cord injury. The research aims to better understand...
- This federal Project Grant award of $465,500.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research focused on developing a close-loop deep brain optoacoustic stimulation system with sub-millimeter precision. The award was provided to the Trustees of Boston University, a private non-profit research university, to conduct this...
- This federal Project Grant award of $164,516 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding supports a research project at New York University School of Medicine to investigate the neural mechanisms underlying speech planning and its relationship to speech disorders in Parkinson's disease patients. Specifically, the project aims to study...
- This federal Project Grant award, valued at $147,486, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The purpose of this award is to investigate the function of a ciliary protein in neural development, with a focus on uncovering novel molecular mechanisms involved in synapse formation that may be relevant to neurological disorders. Using C. elegans as...
- This federal Project Grant award of $458,189 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research focused on understanding how specific membrane-remodeling factors regulate oligodendrocyte membrane dynamics and myelination in the central nervous system. The research aims to elucidate the mechanisms by which these factors shape...
- This $616,200 Project Grant was awarded on February 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to explore the influence of neuromelanin, a dark pigment, on dopaminergic neurons in Parkinson's disease. The project aims to develop a novel mouse model that accumulates neuromelanin in dopamine neurons to study the resulting...
This federal Project Grant award of $596,989.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding supports research at The Washington University to investigate a novel cortical cause of dystonia, a disabling neurological condition, in children born prematurely. The research aims to better understand how injury to cortical parvalbumin-positive interneurons leads to dystonia through modulation of striatal cholinergic interneuron activity. The award period runs from August 1, 2025 to May 31, 2030. The research findings could help advance early treatment approaches for dystonia in cerebral palsy, which affects 2 out of every 1,000 Americans.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $597.0k | 7/30/25 |