Project Grant R01NS139796
- This federal Project Grant award for $659,325.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to understand the role of mutant IDH1 in glioma pathophysiology and immune response mechanisms. The research will use a novel murine glioma model developed by incorporating genetic lesions into neural progenitor cells using the...
- This federal Project Grant award of $429,000 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to explore the mechanism of Notch inhibition resistance in glioblastoma (GBM) cancer stem-like cells. The goal is to develop novel therapies for this deadly brain cancer. The research project, led by the Regents of the University of Michigan, will identify GBM...
- This federal Project Grant award of $2,813,759.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program. The award supports research to investigate the role of the noradrenergic system and its integration with glutamatergic signaling in regulating neurovascular coupling, which is the process that increases cerebral blood flow to regions of high neuronal...
- The Project Grant award of $528,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research to reveal the molecular basis of microtubule-intermediate filament interactions. The research will focus on understanding how microtubules and neurofilaments, which are key cytoskeletal components in myelinated axons, are adapted to form specialized cytoskeletal arrays that regulate cell shape and...
- The federal Project Grant award R01NS139914 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $582,883 award, effective December 1, 2024 through November 30, 2029, supports research by the Regents of the University of California at Riverside to study the role of CAS adaptor proteins in cortical axon pathfinding and the development of proper neural...
- This federal Project Grant award of $770,502.00, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand the molecular mechanisms by which collagen IV regulates TGF-beta signaling and its role in cerebral small vessel disease (CSVD). The research will use mouse models to perform intravital imaging of the cerebral vasculature and...
- This Project Grant award of $427,625 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is funding research to develop a toolbox for studying proteome plasticity in brain endothelial cells. The research aims to further understand the mechanisms of brain blood flow regulation, which is critical for addressing neurological disorders like Alzheimer's disease where disruption of...
- This federal Project Grant award of $754,066 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to unravel the complexities of the mechanistic target of rapamycin (mTOR) signaling network in neurons. The research aims to map the entire mTOR protein interaction network in neurons, revealing how these interactions reconfigure in response to cellular...
- This federal Project Grant award of $118,395.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to identify astrocyte-secreted factors, such as the class 3 semaphorin SEMA3C, that may contribute to neuronal and behavioral deficits in Rett syndrome and Fragile X syndrome. The research aims to test if reduction of astrocyte...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $373,778 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Research Foundation For The State University Of New York (Stony Brook University) to establish a novel vasculature database and analytical platform for mouse brain vasculature. The project aims to develop topology-preserving vessel segmentation algorithms and advanced statistical models...
This Project Grant award, valued at $597,722.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research to investigate a novel mechanism of Ras regulation necessary for normal vascular development, as the Ras-mitogen-activated protein kinase (MAPK) signaling pathway is a critical regulator of blood vascular development and function. The research aims to elucidate the role of the Rasa1 C2 domain in the regulation of Ras cycling, as mutations in this domain have been linked to vein of Galen arteriovenous malformations, a common pediatric cerebrovascular malformation. The award was made to the Regents of the University of Michigan, with a performance period from August 1, 2025 to June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $597.7k | 7/28/25 |