Project Grant R01NS138258

Award Date 4/21/25
Completion Date 3/31/30
Dollars Obligated $656K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
University City, MO 63130, USA
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This federal Project Grant award R01NS138258 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $655,968.00 to The Washington University in University City, Missouri to conduct research on the molecular mechanisms and neurological implications of BK potassium channel variants.

The research aims to unravel the genotype-phenotype connections of three specific gain-of-function BK channel variants and their impacts on neuronal activity and mouse behaviors. The project also involves strategically designing and testing variant-specific modulators to mimic or mitigate the effects of these BK channelopathies, with the goal of developing more targeted therapeutics. Through molecular analysis, mouse model development, and innovative drug design, this 5-year research project aspires to advance the understanding of BK channelopathies and accelerate precision medicine solutions for neurological disorders.

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