Project Grant R01NS137084

Award Date 4/1/25
Completion Date 2/28/30
Dollars Obligated $516K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Nebraska, USA
Similar Awards
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $208,366 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Regents of the University of Michigan to conduct research on the neural mechanisms underlying narcolepsy symptoms. The goal of the project is to clarify how monoaminergic systems and limbic-brainstem projections regulate muscle atonia and disrupted sleep patterns in individuals with narcolepsy....
The National Institute of Mental Health (NIMH) awarded a $187,431 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of North Carolina at Chapel Hill (UNC-CH) to study the interaction between developmental sleep disruption and genetic vulnerability in autism spectrum disorder (ASD). The goal is to establish developmental sleep disruption as a key risk factor for ASD by examining its effects in genetically vulnerable mouse models, specifically those with mutations in...
The National Institute of Neurological Disorders and Stroke (NINDS) has awarded a $443,121 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of California Santa Cruz. This two-year grant, with a period of performance from July 1, 2024 to June 30, 2026, will leverage innovative in situ cryo-electron microscopy (cryo-EM) techniques to study dysregulated protein synthesis, or translation, in an autism spectrum...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 Mental Health Research Grants aims to examine the relationship between early sleep disturbance, functional brain networks, and developmental trajectories in typical and atypical neurodevelopment. The $121,424 award to the University of California, Los Angeles (UCLA) will enable the following key activities over a 3-year period from September 2024 to August 2027: Analyze how sleep latency...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $419,038 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of North Dakota (UND) from September 17, 2024 to August 31, 2027. The goal of this grant is to develop a miniature selective plane illumination fluorescence microscope for high-resolution volumetric imaging of neural activity, including astrocytes, in freely behaving mice....
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $813,596.00 to The Trustees of the University of Pennsylvania to investigate sleep regulation and function during early development. The research aims to define the cellular and circuit properties of sleep across developmental stages, examine mechanisms controlling the emergence...
This federal Project Grant award of $2,049,254.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research into the role of transient neuronal connectivity in healthy brain development and its implications for Fragile X Syndrome, a leading genetic cause of autism. The research aims to investigate the mechanisms by which sensory and neuromodulatory inputs establish transient connections with inhibitory neurons...
This $2,965,125 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) aims to determine how neuronal population dynamics during non-rapid-eye-movement sleep (NREMS) regulate cortical-striatal coupling and impact behavioral automaticity versus flexibility. The project, titled "ROLE OF COORDINATED MULTI-AREA REACTIVATIONS DURING TRANSITIONS BETWEEN AUTOMATIC AND FLEXIBLE BEHAVIORS", is funded under the 21st Century Cures Act - Brain...
This Project Grant award of $567,704.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the neural mechanisms underlying sleep disturbances in Smith-Magenis Syndrome (SMS), a neurodevelopmental disorder. The University of Michigan will conduct this research using a diurnal rodent model of SMS developed through CRISPR gene editing. The...
The Washington University Office of Sponsored Research Services Division received a $427,625 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to unravel the role of satellite glial cells in sensory hypersensitivity in Fragile X Syndrome, a leading genetic cause of autism spectrum disorders. Key activities include: Examining how...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $515,898 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Nebraska Medical Center (UNMC). This 5-year grant, effective from April 1, 2025 to February 28, 2030, aims to investigate the contribution of astrocytes, a type of glial cell, to sleep/wake disturbances in Fragile X Syndrome (FXS) and Autism Spectrum Disorder (ASD). The research will longitudinally assess sleep architecture in FXS mouse models, measure cortical astrocyte calcium signaling dynamics during sleep-wake cycles, and determine the causal relationship between altered astrocyte calcium signaling and sleep impairments using genetic and chemogenetic approaches. This innovative, multifaceted study is expected to provide critical insights into the molecular and cellular mechanisms underlying sleep disturbances in FXS, which can inform the development of astrocyte-targeted therapies.

Generated 4/8/25, 4:15 AM