This Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to investigate the role of complement-mediated inflammation in exacerbating stroke outcomes in mice with type 2 diabetes. The total award amount is $604,795.00 and the project period runs from December 1, 2024 to November 30, 2029. The awardee, Northern California Institute for Research and Education, Inc. (NCIRE), will use single-cell transcriptomics, multiphoton imaging, and other advanced techniques to determine how complement activation and myeloid cell infiltration into the brain contribute to worse stroke outcomes in the context of type 2 diabetes. The findings are expected to provide significant insights into the underlying mechanisms and potential therapeutic targets for mitigating the impact of type 2 diabetes on stroke prognosis.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $604.8k | 11/28/24 |