This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $669,092.00 to the University of Cincinnati to conduct research on the metabolomics of intracerebral hemorrhage (ICH) recovery. The project, titled "METABOLOMICS OF ICH RECOVERY (METABOL-ICH)", aims to leverage existing samples from two large genetic...
This $296,108 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders will support research at the Scripps Research Institute to investigate how mechanosensation at the choroid plexus contributes to intracranial pressure (ICP) regulation in health and disease. The project aims to characterize the role of the mechanosensitive ion channel Piezo1 in choroid plexus...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, will support research under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $502,292 grant awarded to The Johns Hopkins University will investigate the role of copper in the choroid plexus, a key tissue that produces cerebrospinal fluid and forms the blood-brain barrier. Specific aims...
This Project Grant award of $704,313 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to advance a prognostic and monitoring biomarker of neutrophil-driven secondary brain injury in spontaneous intracerebral hemorrhage. The primary objective is to define and validate a standardized protocol to detect specific neutrophil biomarker levels as a potential prognostic and...
This federal Project Grant award of $149,294 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the role of the Zic2 transcription factor in regulating Hedgehog signaling and chromatin dynamics in the developing zebrafish forebrain. The University of Wisconsin-Madison is conducting this 1-year research project to identify Zic2...
This $624,583 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research at the University of Washington to identify potential therapeutic targets for preventing ischemic stroke. The project will leverage existing plasma samples, genomic data, and electronic medical records from the Heart and Vascular Health Study to evaluate...
This Project Grant award of $2,403,545 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), supports research to examine the epigenetic mechanisms linking social determinants of health (SDOH) exposures to vascular cognitive impairment and dementia (VCID) after intracerebral hemorrhage (ICH) stroke. The research, titled REACH-EPIVCID, will identify...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $439,239.00 to the Beckman Research Institute of the City of Hope to develop a novel minimally invasive neurosurgical device for efficient evacuation of intracerebral hematomas. The goal is to fabricate and evaluate the feasibility of this "REMIDE" device, which aims to rapidly and...
This federal Project Grant award of $221,120.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to improve neural progenitor (NP) survival and migration for the treatment of neurodegenerative diseases and brain injuries. The project investigates the potential of adult central nervous system (CNS) endothelial cells to express developmental...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the pathogenic mechanisms of inflammatory subventricular zone injury in preterm infants. The $635,386 award to Duke University aims to define immune signatures associated with the development of subventricular zone echogenicity in preterm infants with...
This $537,508 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to understand the role of endogenous zinc protoporphyrin (ZnPP) in intracerebral hemorrhage (ICH)-induced brain damage. The research aims to elucidate the mechanisms by which ICH triggers ZnPP formation and how ZnPP contributes to neurotoxicity, as well as evaluate strategies to pharmacologically inhibit ZnPP-mediated brain injury. A sub-award of unspecified amount will support collaborative research efforts at the University of New Mexico Health Sciences Center. The findings from this 5-year project are expected to provide new insights into the pathophysiology of ICH and pave the way for developing novel therapies.