This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $498,444 to The Administrators Of Tulane Educational Fund (Tulane University) to research the effects of HIV-associated extracellular vesicles on mitochondrial dysfunction in brain microvessels. The project aims to determine how HIV-free extracellular vesicles and their contents, including fibrinogen and HIV-Tat protein, impact mitochondrial function and blood-brain barrier dysfunction in a mouse model. The research also explores the potential for mesenchymal stem cell-derived extracellular vesicles to reverse these detrimental effects. This work is intended to increase understanding of the mechanisms underlying HIV-associated neurocognitive disorders and explore new therapeutic approaches. The project period is from July 10, 2024 to June 30, 2029.
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