P-icecap extended

Active Project Grant Awarded Last action

Award ID
R01NS135628
Recipient
Awarding agency
Obligated
$2,599,174

Award facts

Completion date 53% complete
Place of performance
Baltimore, MD 21205, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Children who survive out-of-hospital cardiac arrest (ohca) have high rates of disability and substantial caregiver burden 1-year after arrest, yet little is known about longer term child function, caregiver burden, or the factors influencing these outcomes. Prior studies of outcomes more than 1-year after ohca used small/single-site samples, included only children presenting for clinical follow-up, or combined children with ohca with those with in-hospital arrest despite very different characteristics. Our team capitalized on the first major multi-center clinical trial for children with ohca (thapca-OH, 2009-2012) to yield the most detailed data on 1-year adaptive functioning outcomes. One year after ohca, child functioning was divided across 3 disability levels (1/3 with no disability, 1/3 with mild/moderate disability, 1/3 with severe disability). Family burden was high in this cohort and associated with greater child disability. Almost a third of these children were 60% were 6 years of age at follow-up; 2) identify predictors of better child adaptive functioning 2 and 4 years after ohca based on level of child disability at 1-year; 3) identify predictors of lower caregiver/family burden at 2 and 4 years after ohca based on level of child disability at 1-year. We will enroll 350 participants after the 1-year p-icecap follow-up is complete and collect data centrally at kennedy krieger institute via electronic interim surveys and 2- and 4-year telephone interviews. The subset of children >6 years with functional communication will participate in centralized, virtual neuropsychological evaluation.

Transactions

Action Obligated Date
Amendment $625,240
Amendment $572,494
Amendment $700,720
Original award $700,720

Subawards

Subrecipient Amount Awarded
Regents Of The University Of Michigan Univ of Michigan, Scope of Work: Dr. Silverstein will contribute to data interpretation and analysis and is particularly interested in evaluating the… $41,123
Central Michigan University Sub - CMU, Dr. Lauren Yagiela: Scope of Work: Central Michigan University (CMU) will serve as a non-enrolling site for “Pediatric Influence of Cooling… $9,188
The Children's Hospital Of Philadelphia Dr. Topjian will participate in weekly meetings to discuss; 1) coordination between the parent trial (PICECAP) and this project; 2) strategies to promote… $25,331
Central Michigan University CMU will serve as a non-enrolling site and will provide the collaboration with expertise in caregiver and family outcomes and measurements, including those… $16,574

Quick answers

Who received award R01NS135628?

R01NS135628 was awarded to Hugo W. Moser Research Institute At Kennedy Krieger, Inc. by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on March 1, 2024.

How much is award R01NS135628 worth?

$2,599,174 has been obligated on R01NS135628.

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