This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,550,682 to The Research Foundation For The State University Of New York to conduct research on mechanisms controlling central nervous system (CNS) myelin sheath length. The research aims to identify developmental processes that regulate myelin formation and determine how axon diameter serves as a primary instructive cue for establishing myelin sheath length. The project will leverage primary oligodendrocyte-microfiber cultures, ex vivo slice cultures, and in vivo tissue analysis to investigate how oligodendrocyte mechanotransduction, calcium signaling, and translational regulation coordinate myelin sheath growth. Findings from this 5-year project, which began on July 1, 2024, are expected to inform strategies for restoring proper myelin architecture in neurological disorders.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $483.2k | 5/26/25 | ||
| Not listed | $533.8k | 6/26/24 | ||
| Not listed | $533.8k | 6/26/24 |