This Project Grant award of $643,262 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The funding supports research at the University of California, San Francisco (UCSF) to investigate the role of the lateral habenula brain region in both nociceptive (pain) and affective (depression) components of chronic pain.
The key objectives are to systematically examine the anatomical, neurophysiological, and behavioral contributions of lateral habenula projections to the parabrachial nucleus (which transmits pain signals) and the dorsal raphe nucleus (which is implicated in depression). This research aims to elucidate the neural circuit basis for the relationship between chronic pain and major depressive disorder, with the goal of identifying potential therapeutic targets.
UCSF is collaborating with Rutgers, The State University on a sub-award to provide anatomical research expertise for the project. The proposed research represents an important opportunity to advance understanding of pain-depression comorbidities and develop more effective interventions.
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