Forecasting migraine attacks

Active Project Grant Awarded Last action

Award ID
R01NS121233
Recipient
Awarding agency
Obligated
$4,518,840

Award facts

Completion date 94% complete
Place of performance
Boston, MA 02114, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
For the millions of individuals who experience migraine each year, treatment typically consists of reactively treating attacks only after experiencing disruptive pain and secondary symptoms. Because individual migraine attacks are unpredictable to most sufferers, abortive medications are not used early or effectively, and strategies to preemptively stop developing attacks cannot be formulated. By formalizing the daily risk for an attack, individuals will be better prepared to use existing abortive therapies and reduce the suffering associated with any single attack. Our team has previously built and tested the headache prediction-i (hapred-i) and headache prediction-II (hapred-II) models, which are simple migraine forecasting models that are based on daily stress. Despite their promise, these models exhibit several weaknesses that would prevent them from broad clinical use. The objective of this project is to evaluate a new forecasting model that has improved predictive power. To accomplish this, several important predictors have been added to the existing model, and the parameters of the new model will be continuously updated using bayesian estimation. In the new hapred-III model (aim 1), the forecasting window is reduced from 24 to 12 hours, temporal statistical predictors have been added, and additional predictors (e.g., sleep, mood, medication use, prodromal symptoms, and self-prediction) will be tested for improved performance. To allow the model to be more easily deployed (aim 2), predictors of the model parameters will be examined. These predictors will better inform the prior probabilities of the model parameters and will reduce the need to collect weeks or months of data from each individual before generating reliable forecasts.

Transactions

Action Obligated Date
Amendment $419,238
Amendment $375,325
Amendment $29,347
Amendment $29,347
Amendment $377,315
Amendment $377,315
Amendment $377,315
Amendment $422,001
Amendment $422,001
Amendment $422,001
Amendment $422,001
Amendment $422,817
Original award $422,817
Show all 13

Subawards

Subrecipient Amount Awarded
Nex7 LLC Maintenance of the headache forecasting system that was previously created in conjunction with Dr. Houle. This is a web-based portal that collects participant… $639,450

Quick answers

Who received award R01NS121233?

R01NS121233 was awarded to The General Hospital Corporation by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on February 1, 2022.

How much is award R01NS121233 worth?

$4,518,840 has been obligated on R01NS121233.

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