Project Grant R01MH144465
- The National Institute of Mental Health awarded President and Fellows of Harvard College $674,028 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the determinants and function of tonic dopamine signaling in the striatum. The research develops and applies real-time measurement methods to distinguish tonic dopamine (slowly changing baseline levels) from phasic dopamine (rapid transient signals) in mice across multiple behavioral contexts. The project...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $543,711 on August 20, 2026, under the Mental Health Research Grants program (CFDA 93.242, Assistance Listing R01MH145508) to investigate endocannabinoid-mediated inhibitory synaptic mechanisms of hippocampal plasticity using all-optical physiology. The research employs simultaneous patterned optogenetic stimulation and genetically targeted voltage imaging to track synaptic plasticity with millisecond and...
- The National Institute of Mental Health awarded Massachusetts Eye and Ear Infirmary $666,010 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study co-transmission of GABA and glutamate in cortical circuits and the role of neuromodulatory inputs in adult cortical plasticity. The recipient will employ anatomical circuit tracing, whole-cell electrophysiology, and in vivo two-photon imaging in mouse cortex to investigate how cholinergic and serotonergic...
- The National Institute of Mental Health awarded the President and Fellows of Harvard College, through its Harvard T.H. Chan School of Public Health division, $418,000 on August 10, 2026, to identify epigenetic biomarkers that predict the risk and progression of depression among young adolescents under the Mental Health Research Grants program (CFDA 93.242). The recipient will investigate how DNA methylation and microRNA expression mediate the effects of early life stress on adolescent...
- The National Institute of Mental Health awarded the President and Fellows of Harvard College $784,177 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate techniques intended to alter the feelings associated with memories through reactivation-induced memory change (RIMC). The research examines three specific aims: whether RIMC interventions can diminish negative feelings elicited by memories of negative events; how RIMC mechanisms may enhance negative...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $426,991 under the Mental Health Research Grants program (CFDA 93.242) on August 3, 2026, to support research decoding medial prefrontal cortex (MPFC) plasticity across developmental life stages. The recipient is investigating critical periods of synaptic plasticity in the MPFC using high-throughput assays measuring long-term potentiation in mouse brain slices via multielectrode recording arrays. Aim 1 maps...
- The National Institute of Mental Health awarded Trustees of Boston University $449,625 on July 9, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct basic neuroscience research on behavioral functions of cotransmission in cost/benefit decision-making. The research examines how dopamine release in distinct striatal subregions supports different forms of learning—reward-based versus threat-based—and tests a specialized neural circuit linking the tail of the striatum,...
- The National Institute of Mental Health awarded Duke University $315,364 on November 1, 2025, under the Mental Health Research Grants program (CFDA 93.242) to support research on circuit-specific plasticity mechanisms for habitual behavior. The project, titled "Circuit-Specific Plasticity Mechanisms for Habitual Behavior," investigates how cortical inputs to the striatum undergo long-lasting modifications during the transition from goal-directed to habitual action strategies. The...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology (MIT) $803,849 on June 3, 2026, as a Project Grant under the Mental Health Research Grants program (CFDA 93.242) to conduct brain-wide analysis of input/output relationships in the reward system. MIT will use functional magnetic resonance imaging (fMRI) techniques to study integrated input/output relationships between brain regions involved in reward-related tasks. The research centers on a novel genetically...
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
The National Institute of Mental Health awarded $452,386 to President and Fellows of Harvard College on September 1, 2026, to study the plasticity of synaptic cotransmission in the mouse lateral habenula under the Mental Health Research Grants program (CFDA 93.242). The research investigates how changes in the valence of learned associations induce synaptic plasticity in the lateral habenula—a brain structure implicated in mood disorders—and subsequently alter downstream dopamine signaling. The work focuses on synapses in the lateral habenula that simultaneously release excitatory and inhibitory neurotransmitters, using mice and combined behavioral and electrophysiological studies to test whether animals rapidly remapping environmental associations trigger measurable plasticity at these dual-transmitter sites. Harvard Medical School, operating through the Office of Research Administration, is the recipient and place of performance in Boston, Massachusetts. The period of performance extends from September 1, 2026, through May 31, 2031. This is a Project Grant, an assistance type typical of NIMH's mission to advance understanding and treatment of mental illnesses through basic and clinical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $452.4k | 8/14/26 |