Project Grant R01MH144153
- The National Institute of Neurological Disorders and Stroke awarded the University of North Carolina at Chapel Hill $615,286 on August 14, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the relationship between UBE3A mosaicism and Angelman syndrome phenotypic severity. The award funds research using complementary genetic approaches to evaluate how varying percentages of UBE3A-expressing and UBE3A-deficient neurons...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $427,625 Project Grant to the University of Wisconsin–Madison (UW-Madison) effective June 1, 2025, through May 31, 2027, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This project aims to identify cell-type-specific and developmental-stage-specific ubiquitinated proteins in UBE3A (ubiquitin protein ligase E3A) mutant mice to...
- The National Institute of Mental Health awarded The Washington University $763,894 on June 19, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of the ZNF292 gene in cortical development and neurodevelopmental disorders. The research employs complementary experimental systems—mouse knockout models and human pluripotent stem cell-derived neurons carrying six pathogenic ZNF292 variants identified in patients with autism spectrum disorder, intellectual...
- The National Institute of Child Health and Human Development awarded The Ohio State University $426,914 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Assistance Listing 93.HDR) to investigate microRNA mechanisms in Angelman syndrome. The research targets dysregulated microRNA expression, specifically the mir-183/96/182 cluster identified as significantly downregulated in Angelman syndrome model mice. The study tests whether...
- The National Institute of Mental Health awarded The Washington University $735,920 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neural mechanisms of threat learning and avoidance behaviors. The research elucidates the temporal dynamics and causal roles of neurons in the supramammillary nucleus during threat learning, avoidance, and extinction using fiber photometry, optogenetics, and behavioral assays. The project determines whether these...
- The National Institute of Mental Health awarded The Washington University $147,268 on February 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the function of autism spectrum disorder risk genes RFX3 and RFX4 during human cortical development. The research examines how pathogenic mutations in the genes encoding regulatory factor X3 and X4 transcription factors contribute to autism spectrum disorder and other neurodevelopmental disorders. The investigator...
- The National Institute of Mental Health awarded The Regents of the University of California, San Francisco (UCSF) $568,746 on August 11, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the cellular mechanisms by which autism-associated protein SYNGAP1 functions at the primary cilium. The funded research tests the hypothesis that autism spectrum disorder risk genes play pleiotropic roles across subcellular compartments, including functionally significant roles...
- The National Institute of Mental Health awarded University of California, Los Angeles $764,785 under the Mental Health Research Grants program (CFDA 93.242) on July 16, 2026, to investigate context-dependent disease mechanisms in neurodevelopmental disorders, specifically the 16p11.2 chromosomal deletion (16PDEL) implicated in autism, intellectual disability, and ADHD. The project will use a proprietary in vitro human stem cell platform called the Cell Village to conduct high-throughput...
- The National Institute of Mental Health awarded The Washington University $110,595 on August 17, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the feasibility of gene therapy for Tatton Brown Rahman Syndrome (TBRS), a rare neurodevelopmental disorder caused by mutations in DNMT3A. The project, led by an investigator identified as Kim, comprises two aims. Aim 1 employs spatial transcriptomics and single-nucleus RNA sequencing to assess how DNMT3A loss...
- The National Institute of Mental Health awarded Children's Research Institute $654,005 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the function of paralaminar amygdala neurons from adolescence to adulthood using a mouse model. The recipient will examine how paralaminar nucleus neuronal responses change over the adolescent-to-early-adulthood transition, determine the necessity and sufficiency of these neurons in that transition, and characterize...
The National Institute of Mental Health awarded The Washington University $641,417 under the Mental Health Research Grants program (CFDA 93.242) on August 6, 2026, to investigate the neuronal pathways affected by loss of UBE3A activity in Angelman syndrome and leverage those findings for therapeutic design. The research characterizes the postnatal targeting of asparagine synthetase (ASNS) and the integrated stress response (ISR) in a mouse model of Angelman syndrome, and examines the role of ASNS in neuronal development. Preliminary proteomics studies identified ASNS as a substrate of UBE3A; in Angelman syndrome model mice lacking a copy of maternal UBE3A, ASNS protein levels are elevated, global amino acid levels are altered, and phosphorylated eukaryotic translation initiation factor 2-alpha (p-EIF2A) levels increase. Genetic correction of ASNS overabundance improved behavioral phenotypes and microcephaly in these models. Successful completion of this work will identify therapeutic targets for Angelman syndrome treatment and provide new insights into the role of ASNS and the ISR in neuronal development and disease. Work is performed in St. Louis, Missouri, with a period of performance extending through May 31, 2031. The award is structured as a project grant, the standard assistance type for NIMH research awards with project periods not exceeding five years.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $641.4k | 8/10/26 |