Project Grant R01MH141929

Award Date 6/16/25
Completion Date 3/31/30
Dollars Obligated $633K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
New York, USA
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  1. Investigating the spatial and temporal summation rules governing multi-electrode microstimulation in primate prefrontal cortex to uncover principles of nonlinear summation and interaction effects.

  2. Introducing a novel data-driven algorithm called Input/Output Control (I/O-CTRL) that predicts optimal stimulation patterns to evoke specific neural activity states without prior knowledge of circuit dynamics.

  3. Exploring how neural perturbations in prefrontal cortical circuits influence decision-making in primates through closed-loop adaptive stimulation.

This transformative research aims to advance brain-computer interfaces, inform treatments for motor and cognitive disorders, and uncover fundamental principles of brain function. The award period runs from June 16, 2025 to March 31, 2030.

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