Project Grant R01MH140472
- The National Institute of Mental Health awarded the University of Illinois at Chicago $110,228 on January 1, 2027, under the Mental Health Research Grants program (CFDA 93.242) to investigate menstrual cycle effects on mood episodes and suicidality in adolescent female psychiatric patients. The project will examine whether cyclical fluctuations in ovarian hormones function as a biological trigger for suicidality in adolescents with brain sensitivity to hormonal changes. The study builds on a...
- The National Institute of Mental Health awarded the University of Illinois $100,228 on September 30, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct qualitative research on implementation of suicide prevention evidence-based practices in outpatient pediatric behavioral health settings. The recipient will recruit pediatric mental health clinicians, youth patients ages 12–18, and patient caregivers from public outpatient child psychiatry clinics to participate in...
- The National Institute of Mental Health awarded the University of North Carolina at Chapel Hill $163,866 on November 1, 2025, under the Mental Health Research Grants program (CFDA 93.242) to examine estradiol variability's effects on dopaminergic reward circuitry in perimenopausal anhedonia. The recipient will conduct research examining the neurobiological mechanisms linking estradiol flux and anhedonia during perimenopause using simultaneous PET-MR imaging. The work comprises four objectives:...
- The National Institute of Mental Health awarded Northwestern University $714,760 on July 21, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a neuroimaging ancillary study investigating dopaminergic mechanisms of depression and antidepressant response in persons with HIV. The study will enroll 48 participants from a larger clinical trial comparing pramipexole (a dopamine agonist) against escitalopram (an SSRI) for antidepressant efficacy in major depressive...
- The National Institute of Mental Health awarded the University of Pittsburgh $381,463 on September 19, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate neurocognitive responses to social threat and their links to social connectedness and suicidality in adolescent girls. The research employs multivariate electroencephalogram (EEG) decoding to assess neural representation of social threat information in working memory, ecological momentary assessment (EMA) to...
- The National Institute of Mental Health awarded Yale University $1,678,658 under the Mental Health Research Grants program (CFDA 93.242) on May 1, 2026, to conduct the first known in vivo human positron emission tomography imaging study measuring how menopause affects synaptic density in the corticolimbic regions of the brain, whether major depressive disorder exacerbates menopause-related alterations in synaptic density, and how these synaptic changes correlate to objective and subjective...
- The National Institute of Mental Health awarded the University of Illinois $440,908 on July 27, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a project investigating the roles of the prefrontal cortex and ventral hippocampus during adolescence in the maturation of social and cognitive behaviors. The research examines how changes in GABAergic inhibitory transmission in these limbic structures contribute to the refinement of higher cognitive functions and social...
- The National Institute of Mental Health awarded the Research Foundation For Mental Hygiene, Inc. (operating as New York State Psychiatric Institute) $3.295 million on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neural components of stress response and suicide behavior, with emphasis on ketamine's preventive impact. The funded research will examine how naturalistic stress interacts with risk factors to facilitate the transition from suicidal...
- The National Institute of Mental Health awarded the University of Wisconsin–Madison $1.644 million on June 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a mechanistic analysis of the transition from nonsuicidal to suicidal self-injury in adolescents. The research project will employ a multi-method longitudinal approach to follow adolescents aged 13–17 over a two-year period through February 28, 2031. The study aims to identify which factors predict...
- The National Institute of Mental Health awarded Wayne State University $149,190 on September 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a two-day comparative study of endocannabinoid system function in adolescents with and without suicidal ideation. The research compares endocannabinoid concentrations at rest and in response to acute psychosocial stress in 30 adolescents ages 14–17 with suicidal ideation and moderate depressive symptoms against 30 matched...
The National Institute of Mental Health awarded The University of Chicago $719,592 on August 17, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a computational pharmacologic fMRI study examining the neurobiological mechanisms linking ovarian steroid hormones to suicidality in females. The study, titled "Parsing the Idiographic Neuroendocrinology of Suicidality (PINES)," combines clinical trial data, fMRI acquisition and analysis, and group iterative multiple model estimation to identify behavioral and neural pathways underlying the anti-suicidality benefits of estradiol observed in three prior placebo-controlled crossover trials. The research targets perimenstrual suicidality, a phenomenon in which suicidal ideation and depressive symptoms worsen during the luteal phase when estradiol and progesterone levels fall. The proposed work includes a two-month longitudinal baseline recruiting 200 outpatients (150 expected completers) and a crossover placebo-controlled trial with 75 recruited participants (60 expected completers) to examine estradiol administration effects during perimenstrual weeks. Specific aims include identifying idiographic hormone-symptom networks associated with proximal suicide risk and distinguishing subgroups showing estradiol-driven suicidality, progesterone-driven suicidality, or both. Work is performed in Chicago, Illinois. The award runs through April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $719.6k | 8/19/26 |