This $157,000 Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants supports research to investigate the role of dopamine receptor signaling in astrocytes and its impact on prefrontal cortex (PFC) functions. The key objectives are to determine how D2 dopamine receptor (D2R) signaling in astrocytes influences the activity of neighboring cells and induces microglia proliferation, which could impact PFC-dependent behaviors,...
The National Institute of Mental Health (NIMH) awarded a $1,974,599 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Massachusetts Institute of Technology (MIT) on July 18, 2024. The purpose of this grant is to investigate the role of top-down dendritic processing in credit assignment and cortical dynamics. Specifically, the researchers will: (1) establish the relationship between single-neuron dendritic integration and circuit dynamics, studying how this changes during...
The National Institute of Mental Health (NIMH) awarded a $440,000 Project Grant (R21MH134002) to Baylor College of Medicine to study astrocyte ensembles and their role in memory formation. The 2-year grant, starting on August 1, 2023, aims to define the properties of astrocyte engrams - the physical substrate of memory that has been underexplored to date. The research will use specialized mouse models and viral tools developed by the investigators to label and manipulate astrocyte ensembles...
The federal Project Grant award R01MH134993, totaling $2,150,657.00, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant aims to determine the mechanisms that lead to the generation of astrocytes, the most abundant cell type in the adult human brain, during the development of the human cortex. The research will trace the lineage decisions of astrocytic progenitors using in vitro experiments and single-cell gene...
This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA program 93.242 Mental Health Research Grants, will support research into the neurocircuitry underlying motivated reward-seeking behavior as a coping mechanism for stress. The $606,029 award, effective August 1, 2024 through July 31, 2025, will be administered by the University of Massachusetts Medical School. The key objectives are to investigate how sub-populations of neurons in the medial...
This $248,998 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research into the neural circuit mechanisms underlying motivation. The principal investigator, a newly appointed Assistant Professor at Dartmouth College, will use in vivo calcium imaging and optogenetic stimulation to study the role of GABA/glutamate co-releasing neurons in the ventral tegmental area (VTA) and their projections to the...
The National Institute of Mental Health (NIMH) awarded a $434,610 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Florida Institute of Technology Inc. (Florida TECH) to develop light-triggered molecular tools critical for understanding the brain's neural network. The 3-year project, awarded on December 16, 2024, aims to create photoswitchable molecular "cages" that can precisely control calcium ion concentrations to enable neuroscientist collaborators,...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $1,097,250 to Augusta University Research Institute, Inc. to investigate the role of astrocyte-neuron interactions and glutamatergic signaling in regulating social novelty recognition behaviors. The research aims to elucidate the detailed mechanisms by which astrocyte dysfunction and abnormal glutamate regulation contribute to social behavioral...
This three-year, $3.456 million project grant from the National Institute of Mental Health (NIMH) Mental Health Research Grants program (CFDA 93.242) will fund research into the role of microglia in neurodevelopmental disorders. The grantee, Cold Spring Harbor Laboratory, will merge two-photon imaging of microglia and synapses in the brains of live mice with single-cell genomics and CRISPR screens. This will help define microglia's role in experience-dependent synaptic refinement, a process...
The National Institute of Mental Health (NIMH) awarded a $267,310 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Trustees of Boston University's Medical Campus to study inhibitory neurotransmission in the prefrontal cortex of rhesus macaques. The research aims to understand how compartment-specific inhibition and laminar circuit dynamics in the lateral prefrontal cortex (LPFC) and anterior cingulate cortex (ACC) contribute to cognitive and emotional disturbances in...