This $2,210,781 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research to determine the molecular and cellular mechanisms in A13 dopaminergic cells in the zona incerta that contribute to extinction learning. The research aims to advance the understanding of how dopaminergic signaling modulates extinction learning, which is a core deficit in post-traumatic stress disorder (PTSD). The...
This Project Grant award of $390,000.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program supports research on the neural mechanisms underlying defensive behaviors and their relationship to anxiety disorders, such as post-traumatic stress disorder (PTSD). The research aims to examine how the activity of prodynorphin-expressing neurons in the paraventricular nucleus of the hypothalamus regulates flexible defensive responses,...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports new mentored training in the computational neuroscience of higher-order threat learning and memory in post-traumatic stress disorder (PTSD). The $180,439 award to the University of Texas at Austin aims to build the candidate's expertise in applying advanced computational decoding techniques like multivariate pattern analysis (MVPA) to understand...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $610,152 to Duke University to study the structural and functional architecture of cortico-cerebellar systems in post-traumatic stress disorder (PTSD). The key objectives are to investigate the influence of PTSD, trauma exposure, and PTSD symptom clusters on the functional connectivity of cerebellar subregions, examine the structural...
This Project Grant award of $618,863 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program. The project aims to investigate the neural dynamics of fear circuits in ecological rodent models of risk and trauma. Specifically, the research will: 1) Test the hypothesis that the amygdala functions as a pivotal relay, processing biological threat information from the midbrain and transmitting fear signals to corticolimbic structures...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is focused on understanding the neural mechanisms underlying psychiatric comorbidities across posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and anxiety disorders (ANXs). The $769,753 award will leverage large-scale multimodal neuroimaging datasets from ENIGMA and UK Biobank to identify neural biomarkers and biotypes that can help...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to establish the efficacy and mechanisms of exercise-enhanced fear extinction retrieval and generalization in individuals with post-traumatic stress disorder (PTSD). The $770,654 award, effective June 1, 2025 through May 31, 2030, will fund research to compare the impact of different exercise intensities on fear extinction measures and neural...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $1,462,939.00 to conduct a hybrid effectiveness-implementation trial of massed prolonged exposure (M-PE) treatment for post-traumatic stress disorder (PTSD) comorbid with substance use disorder (SUD). The primary objectives are to compare the effectiveness of M-PE versus treatment as usual (TAU) in reducing PTSD symptoms and substance use...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is intended to support research to understand the genomic basis of post-traumatic stress disorder (PTSD) through integrative analysis of rare genetic variants and other multi-omics data. The $424,175 award, spanning May 2025 to April 2027, will enable researchers at Virginia Commonwealth University to leverage large-scale whole exome and whole genome...
This Project Grant award of $677,261 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program will fund research at the University of New Mexico Health Sciences Center (UNM HSC) to investigate the role of the locus coeruleus, a brain region that produces norepinephrine, in regulating hippocampal neural networks during learning. The project aims to establish a causal link between hippocampal output, norepinephrine release, and the resetting...