This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $234,000.00 to support research investigating how inhibitory synapses in the brain regulate the structure and function of excitatory synapses during development. The primary objectives are to 1) determine how inhibitory synapses heterosynaptically modulate excitatory synapse formation and elimination across brain development, and 2) elucidate the...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,049,254 to Cold Spring Harbor Laboratory to investigate the role of transient neural connectivity in healthy and impaired cortical maturation. The 5-year research project (7/1/2024 - 1/31/2029) aims to elucidate the mechanisms by which sensory inputs and neuromodulation regulate the development of inhibitory neuron connectivity, and...
The National Institute of Mental Health (NIMH) has awarded a $727,248 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Trustees of the University of Pennsylvania, effective September 25, 2024, with a completion date of May 31, 2029. This grant will fund research to examine how mutations in the neurexin1 (NRXN1) gene, a genetic risk factor for multiple neuropsychiatric disorders, impact the function of striatal cholinergic interneurons and midbrain dopamine neurons. The...
This $3,085,041 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support a longitudinal study on adolescent brain maturation and its relationship to psychiatric disorders. The University of Pittsburgh, as the prime awardee, will use advanced neuroimaging techniques at 7 Tesla MRI to examine neuropil growth/contraction and multiplex network dysconnectivity in 210 adolescent subjects, including those at...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research to investigate the impact of species-specific timing of synaptic maturation on cortical circuit and behavioral development. Specifically, the $150,251 award to The Trustees of Columbia University will utilize CRISPR/Cas9 approaches and electrophysiology to characterize the morphological and functional maturation of excitatory and inhibitory...
The National Institute of Mental Health (NIMH) awarded a $553,788 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Northwestern University to investigate the microcircuit mechanisms underlying the distributed cortical contributions to working memory. The research aims to understand how genetically identified cell types in the primary visual cortex (V1) and premotor cortex (M2) interact to generate different activity timescales and patterns of recruitment during working memory tasks...
This three-year, $3.456 million project grant from the National Institute of Mental Health (NIMH) Mental Health Research Grants program (CFDA 93.242) will fund research into the role of microglia in neurodevelopmental disorders. The grantee, Cold Spring Harbor Laboratory, will merge two-photon imaging of microglia and synapses in the brains of live mice with single-cell genomics and CRISPR screens. This will help define microglia's role in experience-dependent synaptic refinement, a process...
The National Institute of Mental Health (NIMH) awarded a $775,706 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Pittsburgh on August 9, 2024. The funding will support a prospective study examining the neural, molecular, and functional impacts of reducing anticholinergic burden (ACB) in 80 individuals aged 40-70 with schizophrenia spectrum disorders. The study aims to understand the effects of ACB reduction on cognition, quality of life, neural mechanisms...
The National Institute of Mental Health (NIMH) awarded a $182,993 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to the Research Foundation for Mental Hygiene, Inc. (RFMH), operating as the New York Psychiatric Center. The grant supports a 4-year research project from September 2024 to August 2028 that aims to investigate the role of acetylcholine release in the dorsomedial striatum and its relationship to thalamic activity during reversal learning. The project...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $267,310 to Trustees of Boston University to conduct research on compartment-specific inhibition and laminar circuit dynamics in the primate prefrontal cortex. The research aims to compare the spatial distribution, kinetics, and synaptic physiology of dendritic inhibition in the anterior cingulate cortex (ACC) and lateral prefrontal...