This Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $624,000.00 to the University of Texas Health Science Center at Houston (UTHealth) to develop a platform called mRNADesigner. The goal of this project is to create an integrated deep learning model to optimize the 5'UTR, codon usage, and 3'UTR of mRNA sequences to enhance mRNA stability and translation efficiency for mRNA...
The federal Project Grant award of $1,312,212, awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Medical Library Assistance (CFDA 93.879) program, supports the development of an advanced DNA language model. This innovative computational framework aims to unlock the secrets within DNA sequences by studying them as a form of biological language, similar to the advancements in natural language processing. The project, running from September 1, 2024, to August...
This Project Grant award of $1,012,028 from the National Institute of Environmental Health Sciences (NIEHS) under the Medical Library Assistance (CFDA 93.879) federal grant program aims to develop and validate structure-function-aware large protein language models (SF-PLM) that can be adapted for challenging biomedical research tasks through few-shot learning. The key products and services to be delivered include: (1) large protein language models that incorporate knowledge of 2D and 3D...
The National Science Foundation (NSF) awarded a $1,199,997 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Colorado-Denver. The grant will fund research to improve understanding of the mechanisms underlying messenger RNA (mRNA) localization and translation, and develop machine learning models to better predict protein production from mRNA. The project will apply recent advancements in RNA sequencing technology to study how factors like tRNA abundance and...
This National Science Foundation (NSF) Biological Sciences program grant to Yale University, totaling $940,000 over 3 years beginning March 1, 2024, aims to systematically identify features of human and viral messenger RNAs (mRNAs) that regulate protein production. The project will employ a massively parallel reporter assay to quantify the impact of RNA modifications, structured RNA elements, and cell-specific factors on mRNA translation. Insights gained will provide a comprehensive...
The National Institute of Environmental Health Sciences (NIEHS) awarded a $727,580 Project Grant under the Medical Library Assistance (CFDA 93.879) federal grant program to the University of Texas at Austin (UT Austin). The grant, titled "Building Safety Guards into LLMs for Trustworthy Automatic Simplification of Medical Documents," aims to develop novel natural language processing (NLP) technologies to mitigate risks and improve the reliability of large language models (LLMs) for the...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Medical Library Assistance (CFDA 93.879) program provides $351,000 to the University of Texas Health Science Center at Houston (UTHealth) to develop a trustworthy and high-performance question answering system for electronic health records (EHRs). The key objective is to create a hybrid method that leverages the capabilities of large language models while maintaining the trustworthiness of...
The National Institute of General Medical Sciences (NIGMS) awarded a $300,518 project grant (CFDA 93.859 - Biomedical Research and Research Training) to E&E Bioclub LLC in Indianapolis, IN. The purpose of this 1-year project is to develop an all-in-one platform for the intracellular overproduction of long, single-strand mRNA. This aims to address challenges with current mRNA manufacturing methods, which are constrained by the need for multiple expensive enzymes and reagents, as well as...
This $387,500 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to develop improved computational methods for human gene annotation. The project aims to enhance the accuracy and completeness of the human gene catalog by leveraging massive RNA sequencing datasets and developing new algorithms to process and analyze this data at scale. Key objectives include identifying...
This Project Grant award R01GM155969 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $424,451.00 to the University of Connecticut (UConn) to develop novel biomaterials for intracellular delivery of messenger RNA (mRNA) therapeutics and research tools. The goal is to optimize the biointerface properties of DNA-inspired Janus base biomaterials using computational molecular design and experimental validation to...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Medical Library Assistance (CFDA 93.879) program will provide $351,000 to develop an integrated deep learning model to optimize the 5' untranslated region (UTR), codon usage, and 3' UTR of mRNA sequences. The goal is to enhance the stability and efficiency of mRNA medicines, including those for COVID-19, cancer, and other infectious diseases. The research team at the University of Texas Health Science Center at Houston will focus on creating computational models to systematically optimize these mRNA sequence elements and validate the models through experimental testing of representative mRNA candidates. This work aims to improve the efficacy of mRNA-based therapeutics and vaccines by enabling the design of optimized mRNA sequences. The award has a performance period from August 2024 to July 2028.