Project Grant R01HL185875
- Federal Project Grant Award Summary Boston University Medical Campus received a $150,342 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 30, 2026, with completion targeted for June 30, 2029. The award funds research investigating the mechanisms of a conserved niche endothelial program that directs hematopoietic stem cell (HSPC) migration into bone marrow during stem cell...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $1,072,936 to the University of California, San Diego, effective September 15, 2025, through June 30, 2029, under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports fundamental research investigating protein aggregation mechanisms in hematopoietic stem cells (HSCs), with the primary deliverable being scientific research and discovery designed to advance...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $521,101 Project Grant to the University of Wisconsin–Madison, with an award date of June 15, 2026, and completion date of February 28, 2031, under the Cardiovascular Diseases Research program (CFDA 93.837). The research focuses on defining the mechanisms by which hematopoietic stem cells (HSCs) acquire macrophage-associated markers through trogocytosis—a cellular membrane transfer mechanism—and...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Massachusetts a $425,971 Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) effective July 6, 2026, through June 30, 2028, to develop a biomaterials-integrated microphysiological bone marrow chip model. The project aims to create a physiologically relevant preclinical system that recapitulates the structural and functional interdependence of bone and bone marrow...
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $776,511 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with completion targeted for May 31, 2029. This award supports research to develop and validate a three-dimensional engineered hemogenic vascular niche model designed to elucidate the microenvironmental factors that promote hematopoietic stem...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $1,137,883 to The Trustees of Columbia University in the City of New York (Health Sciences Division) under the Cardiovascular Diseases Research program (CFDA 93.837). The award, effective April 1, 2026, through January 31, 2033, funds research into the "Dynamics and Plasticity of the Hematopoietic Stem Cell Niche." The project will investigate how the bone marrow and...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Florida Division of Sponsored Research $142,568 under the Cardiovascular Diseases Research program (CFDA 93.837) on June 1, 2026, for a project extending through March 31, 2031. This K25 career development award supports a mathematician-data scientist's transition to an independent research career focused on applying machine learning and biomedical data science to predict early and chronic...
- Federal Grant Award Summary The University of South Florida received a $1.47 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 19, 2025, with completion targeted for August 31, 2030. The award funds patient-oriented research investigating the relationship between atrial microvascular and endothelial dysfunction and postoperative atrial fibrillation (POAF), a complication affecting...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $292,500 Project Grant to Sanford Burnham Prebys Medical Discovery Institute effective August 15, 2025, through July 31, 2027, under the Cardiovascular Diseases Research program (CFDA 93.837). This interdisciplinary research project aims to identify and characterize novel microproteins encoded by small open reading frames (SMORFs) that play critical roles in normal hematopoiesis and hematopoietic...
- Federal Project Grant Award Summary The University of Minnesota received a $1.57 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 1, 2026, with completion by February 29, 2028. The award funds mechanistic research into chronic graft-versus-host disease (CGVHD) pathobiology and the development of novel anti-fibrotic therapies. Using state-of-the-art murine models and advanced molecular...
The University of Florida Division of Sponsored Research received a $597,817 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2026 through April 30, 2030. The award funds research to develop novel resources and methodologies for improving hematopoietic stem cell (HSC) transplantation outcomes, with the goal of expanding the donor pool for patients with life-threatening blood and immune system disorders and reducing treatment-related mortality. The research specifically investigates the vascular niche's role in large-scale HSC expansion while preserving self-renewal capacity, focusing on how thrombospondin-1 (THBS1) produced by aged bone marrow endothelial cells impairs HSC function and how neutralizing this protein can restore expansion capability comparable to young blood products. The project will employ gold-standard assays to evaluate HSC and vascular function, while simultaneously developing a humanized murine bone marrow vascular niche model to identify novel angiocrine factors that support human HSC and vascular function. By translating findings on THBS1 neutralization from preliminary data into functional improvements in human blood products and identifying supportive factors from the humanized vascular niche, this research aims to deliver improved ex vivo expansion protocols and therapeutic approaches that enhance HSC transplantation efficacy across a broader patient population.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $597.8k | 7/7/26 |