Project Grant R01HL179089
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $148,296 to Baylor College of Medicine to investigate the molecular drivers of postoperative atrial fibrillation (POAF). The research aims to identify how macrophage-mediated interleukin-6 signaling leads to ryanodine receptor 2 calcium leak, which contributes to the development of POAF. The project period runs from January 31, 2025 to...
- The federal Project Grant award, worth $752,618.00, was provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to study the role of inflammation in postoperative atrial fibrillation (POAF). The award to Baylor College of Medicine aims to advance the understanding of the molecular drivers of POAF, which is a common complication of cardiothoracic surgery. The research will investigate the link between increased infiltrating macrophages,...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $673,598 Project Grant under CFDA 93.837 - Cardiovascular Diseases Research to Baylor College of Medicine in Houston, TX. The grant, titled "Cardiomyocyte-Fibroblast Signaling in Atrial Fibrillation", aims to dissect the molecular and cellular basis of the calcitonin signaling pathway in relation to atrial fibrosis and progression of atrial fibrillation (AF). The research will be conducted using freshly isolated and...
- The University of South Florida was awarded a $2,074,842 Project Grant from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to investigate how post-translational modifications of the enzyme CAMKII during chronic diabetes dysregulate endothelial small-conductance calcium-activated potassium (SK) channels, coronary microvascular endothelial-dependent relaxation, and myocardial blood flow. The grant was awarded on December 15, 2024 with an ultimate...
- This federal Project Grant award of $618,450.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research focused on identifying key regulators of vascular homeostasis and understanding how they maintain normal vascular function. The principal investigator will use a combination of in silico and in vitro screening approaches to identify the RNA-binding protein PABPC1 as a critical suppressor of endothelial cell activation, which can...
- The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $464,502 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to Tarleton State University to create an interactive computer model of the left atrium's electrophysiology. The goal is to study the underlying mechanisms leading to atrial fibrillation, a significant contributor to strokes, heart failure, and acute myocardial infarction. The 3-year project will involve constructing...
- The National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $498,991.40 Project Grant to the University of Arkansas. The grant, effective January 2, 2025 through December 31, 2027, will support the development of microphysiological systems to study the effects of hypoxia (low oxygen levels) on cardiac injury following a myocardial infarction (heart attack) and ischemia-reperfusion injury. The research aims to use microfluidic...
- This federal Project Grant award in the amount of $149,348 was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Florida. The award funds research to investigate the cellular mechanisms involved in acute-intermittent hypercapnic-hypoxia induced phrenic motor plasticity. Specifically, the project aims to monitor phrenic nerve activity in anesthetized rats as a proxy for diaphragm muscle...
- This $726,035 federal grant award was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to The University of Central Florida Board of Trustees. The grant will fund a 5-year research project to map the vagal and spinal afferent innervation of healthy and diabetic rat and human hearts, characterize the structural and functional roles of these cardiac afferent nerves, and integrate the anatomical and functional data onto...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $249,000.00 to The University of Texas Southwestern Medical Center to conduct research on the molecular determinants of atrial fibrillation (AF). The research aims to better understand the gene expression changes central to AF, focusing on the role of the transcription factor TBX5 and the chromatin remodeling protein CHD4 in...
The University of South Florida was awarded a $733,999 Project Grant by the National Heart, Lung, and Blood Institute (NHLBI), under the Federal Grant Program CFDA 93.837 - Cardiovascular Diseases Research. The goal of this patient-oriented research proposal is to investigate how dysfunction in the cardiovascular physiology of atrial microvasculature and endothelium affects post-operative atrial fibrillation (POAF), which is a common complication following cardiac surgery. The key objectives are to: 1) Evaluate microvascular signaling pathways responsible for dysfunction of the atrial microvasculature in POAF patients; 2) Investigate cellular/molecular alterations of atrial endocardial endothelial dysfunction in POAF patients; and 3) Analyze differential genomic expression changes associated with POAF. This 5-year award, effective from September 2025 through August 2030, aims to advance the understanding of the relationship between atrial microvascular/endothelial (dys)function and the development of new-onset POAF, with the potential to inform improved prevention and treatment strategies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $734.0k | 9/18/25 |