Project Grant R01HL185489
- The National Heart Lung and Blood Institute awarded the University of North Carolina at Chapel Hill $777,419 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the muco-obstructive mechanisms underlying bronchiectasis and identify novel therapeutic targets. The research examines bronchiectasis pathogenesis through a revised conceptual model that integrates airway epithelial hypoxia, mucus hyperconcentration, osmotic pressure-driven airway...
- The National Heart, Lung, and Blood Institute awarded the University of North Carolina at Chapel Hill $1.121 million on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research examining how maternal depression intervention affects child respiratory health outcomes in a low-resource setting. The award funds an additional data collection wave of the ongoing BACHPAN birth cohort study in rural Pakistan, which comprises approximately 825...
- The National Heart, Lung, and Blood Institute awarded the University of North Carolina at Chapel Hill $200,137 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop non-invasive tools for assessing aspiration risk in infants with swallowing dysfunction. The project will refine and validate clinical scoring tools based on observable feeding variables and develop artificial intelligence-enabled cervical auscultation methods to detect aspiration during...
- Federal Project Grant Award Summary The University of North Carolina at Chapel Hill received a $233,250 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with completion targeted for August 31, 2028. This pilot research initiative will develop and evaluate anakinra, an interleukin-1 receptor antagonist (IL-1RA) currently approved for rheumatoid arthritis treatment, as a...
- The National Heart, Lung, and Blood Institute awarded the University of North Carolina at Chapel Hill $750,330 on July 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate MUC5AC structure, function, interactome, and its role in airway obstruction. The research addresses the molecular mechanisms by which MUC5AC, an airway mucin, contributes to chronic obstructive pulmonary disease and asthma pathogenesis. The project will define MUC5AC's unique macromolecular...
- The National Heart, Lung, and Blood Institute awarded $777,498 to the University of North Carolina at Chapel Hill on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on multiscale integration of mucin secretion and ion transport rates in asthmatic mucus plug formation and persistence. The research tests the applicability of a biophysical paradigm called the "two-gel" paradigm to asthma pathogenesis, examining whether asthma mucus...
- The National Heart, Lung, and Blood Institute awarded Duke University $215,504 under the Cardiovascular Diseases Research program (CFDA 93.837) on September 12, 2025, to fund research on epithelial cell-mediated fibroblast activation through CTHRC1-TGFB signaling in fibrotic lung diseases. The research investigates mechanisms of fibroblast activation in bronchiolitis obliterans and idiopathic pulmonary fibrosis. Aim 1 evaluates airway epithelial cell-fibroblast interactions contributing to...
- The National Heart, Lung, and Blood Institute awarded the University of North Carolina at Chapel Hill $222,309 on September 1, 2026, for secondary data analysis examining how community and peer-based interventions influence cardiovascular risk in diabetes management populations. The study conducts structural equation modeling across three major programs: 14 projects funded by the Robert Wood Johnson Foundation Diabetes Initiative, 14 evaluation and demonstration projects funded by Peers for...
- The National Heart, Lung, and Blood Institute awarded the University of North Carolina at Chapel Hill $618,352 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the mechanical regulation of endothelial lipid droplet metabolism and its role in vascular dysfunction. The research examines how oscillatory shear stress suppresses triglyceride hydrolysis by inactivating the transcription factor FOXO1, leading to lipid droplet accumulation in...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of North Carolina at Chapel Hill a Project Grant of $233,250 beginning September 1, 2025, and concluding August 31, 2027, under the Cardiovascular Diseases Research program (CFDA 93.837). This research initiative investigates the role of lipid metabolism in regulating lung macrophage activity and phenotypes during acute lung injury, with particular focus on how metabolic changes drive...
The National Heart, Lung, and Blood Institute awarded the University of North Carolina at Chapel Hill $791,870 on September 1, 2026, to design and evaluate an enhanced electronic patient-reported outcome (EPRO) implementation for thoracic surgery patients titled "BETTER REMOTE MONITORING AFTER THORACIC SURGERY EVENTS" (BREATHE), funded under the Cardiovascular Diseases Research program (CFDA 93.837). The project addresses postoperative symptom burden in thoracic surgery patients through systems science methods and implementation science. BREATHE will engage thoracic surgery clinic sites at five institutions in structured workshops to produce contextualized implementation plans. The intervention will be tested in a parallel-group randomized controlled trial enrolling approximately 700 patients over two years against usual care at the five sites. Multilevel determinants of BREATHE will be evaluated using RE-AIM and CFIR frameworks alongside usability surveys and qualitative interviews analyzed through a matrixed multiple case study approach. Patient-centered, clinical, and healthcare utilization outcomes will be compared to usual care over one year post-discharge. Work is performed in Chapel Hill, North Carolina, with the performance period running from September 1, 2026, through May 31, 2031. This is a Project Grant assistance type. The University of North Carolina System Office serves as the parent organization.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $791.9k | 8/27/26 |