Project Grant R01HL184013
- Federal Grant Award Summary Tufts University School of Medicine received a $318,966 project grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on June 30, 2025, with a completion date of January 31, 2028. This grant supports research aimed at characterizing lung resident B1 cells and their functional role in lung homeostasis during development. The research deliverables include scientific investigations...
- Federal Grant Award Summary Brigham & Women's Hospital Inc. received a $710,302 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through May 31, 2029. The award funds research to characterize lung interstitial neutrophils (LINs), a specialized immune cell subset that plays a critical role in bacterial elimination within the lung. The project will investigate the origin,...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $814,387 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) under the Cardiovascular Diseases Research program (CFDA 93.837). The award, effective August 1, 2025 through April 30, 2029, funds research investigating lung vascular Group 3 Innate Lymphoid Cell (ILC3) subpopulations and their roles in antibacterial immunity and vascular regeneration. The...
- Federal Grant Award Summary Florida International University received a $694,398 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 21, 2025, with a completion date of May 31, 2029. The award supports basic research investigating the molecular mechanisms linking mitochondrial dysfunction and inflammation in sepsis-induced acute lung injury (ALI). The research will examine how...
- Federal Grant Award Summary Brigham & Women's Hospital Inc., operating through its Department of Faulkner Pathology, received a $1.34 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 1, 2025, through March 31, 2029. The grant funds research aimed at developing an alternative therapeutic strategy for treating neutropenia-related pneumonia by extending neutrophil survival in the...
- Federal Project Grant Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $1.375 million to the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of sensory neurons in regulating antibody production and immune response to Streptococcus pneumoniae lung infection. The five-year project, initiated August 1, 2025 and concluding April 30, 2030, will examine how...
- Federal Project Grant Award Summary Yale University received a $958,850 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with a completion date of May 31, 2029. This research project focuses on investigating interleukin-1 (IL-1) signaling mechanisms in critically ill children with bronchiolitis to identify disease severity markers and develop therapeutic interventions. The...
- Federal Project Grant Award Summary Florida International University received a $516,250 project grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through July 31, 2027. The award supports the development of novel RhoA nitration inhibitory peptides for treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). The research addresses a critical unmet medical need, as...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $448,250 Project Grant to The Research Foundation For The State University Of New York (operating as Upstate Medical Center) on May 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports the development and evaluation of a lung-targeted immunomodulatory messenger ribonucleic acid (mRNA) therapy designed to treat Acute Respiratory Distress Syndrome (ARDS),...
- Federal Grant Award Summary National Jewish Health received a $702,103 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with completion anticipated June 30, 2029. The project investigates the SFTA2/ADGRF5 signaling axis in alveolar homeostasis, focusing on elucidating how the secreted protein SFTA2 (surfactant-associated protein 2) regulates pulmonary surfactant levels through...
The National Heart, Lung, and Blood Institute (NHLBI) awarded The Feinstein Institutes for Medical Research a $586,866 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective May 15, 2026, through February 28, 2030. The research investigates the critical role of B-1A cells, an immunoregulatory B cell subset, in mitigating acute lung injury (ALI) and acute respiratory distress syndrome—life-threatening inflammatory conditions frequently caused by sepsis or ischemia-reperfusion injury. The project delivers scientific outputs including elucidation of molecular mechanisms by which siglec-G disrupts CD47 "don't-eat-me" signaling, leading to neutrophil-mediated B-1A cell trogocytosis, and investigation of B-1A cell contributions to pulmonary endothelial cell metabolic function and survival. The research culminates in preclinical evaluation of Compound 11 (C11), a novel 11-amino acid oligopeptide derived from CD47 that binds siglec-G and restores protective B-1A cell function. These deliverables represent basic and translational research outputs designed to advance understanding of ALI pathogenesis and develop potential therapeutic interventions to prevent B-1A cell depletion, thereby mitigating ALI severity. The work is conducted at The Feinstein Institutes' facility in Manhasset, New York, supporting the NHLBI's mission to reduce morbidity and mortality from heart, lung, and blood disorders through comprehensive research programs.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $586.9k | 5/19/26 |