Project Grant R01HL175502
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $516,250.00 to Florida International University to develop novel RhoA nitration inhibitory peptides for the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). The research aims to shield RhoA, a key protein, from nitration to protect endothelial barrier function, preserve mitochondrial function, and reduce inflammation during...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $759,983.00 to the University of North Carolina at Chapel Hill to conduct research on the role of neutrophils in lung infections and acute lung injury. The study aims to examine changes in neutrophil transcriptomes and function during Streptococcus pneumoniae pneumonia, with the goal of improving understanding of the lung's immune response and potential...
- The National Heart, Lung, and Blood Institute (NHLBI), via the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $564,445 Project Grant to the University of Texas Health Science Center at Houston (UTHealth) to fund research on "Targeting Hypoxia-Inducible Factors (HIFs) for Heart and Lung Disease." The 6-year grant, starting on March 1, 2025 and ending on December 31, 2031, supports three complementary research projects focused on investigating the upstream regulation...
- The University of Kentucky Research Foundation received a $1,398,770 Project Grant from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of HDL-associated serum amyloid A (SAA) in sepsis-induced acute lung injury and mortality. The project aims to test the hypothesis that systemic SAA-HDL resolves sepsis-induced lung injury and mortality by regulating neutrophil infiltration into the injured lung. The research...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,061,189 to the Regents of the University of Michigan to conduct research on immune crosstalk in lung injury and fibrosis. The key objectives are to study epithelial cell regulation of fibrosis and its interaction with myeloid cells, uncover mechanisms for impaired innate immunity against gram-positive infections in fibrosis, test delivery of targeted therapeutics...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,659,996.00 to the University of Southern California (USC) to investigate the role of the NF-kappaB modulator PDLIM2 in alveolar macrophages and its impact on lung innate immunity, inflammation, and diseases. The research aims to elucidate how alveolar macrophages, which are critical for lung defense, can promote lung cancer and increase vulnerability to...
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $722,667 project grant to the University of Texas Health Science Center at Houston (UTHealth) to conduct research on ribosome dysfunction in lung fibrosis associated with systemic sclerosis (SSc). The 5-year project, spanning from September 1, 2025 to May 31, 2030, aims to investigate the mechanisms by which enhanced ribosome biogenesis leads to an altered...
- The Project Grant award "AIRSPACE CANDIDA COLONIZATION AND LUNG INJURY (AIRCCOLIN)" is funded by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The $719,195 award supports research to investigate the role of Candida species in contributing to lung injury in critically ill, mechanically ventilated patients. Key objectives include understanding how Candida may disrupt lung barrier integrity, trigger neutrophilic...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $233,250 to the University of North Carolina at Chapel Hill (UNC-CH) to investigate the role of lipid metabolism in lung macrophage activity and phenotypes during acute lung injury. The project aims to understand how changes in lipid metabolism alter the function of lung macrophages during influenza A virus infection, which can lead to lung inflammation...
- This $229,608 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research investigating the role of pleural mesothelial cells in lung injury, repair, and regeneration. The award to Mayo Clinic aims to conduct lineage-tracing experiments in mouse models of lung injury and regeneration, and subsequent genomic analysis of the collected pleural mesothelial cells. This research seeks to improve the understanding of repair...
The U.S. National Heart, Lung, and Blood Institute awarded a $694,398 Project Grant to Florida International University to conduct research on the role of mitochondrial dysfunction in sepsis-induced acute lung injury. The 4-year award, effective August 21, 2025, aims to investigate how Toll-like receptor 4 (TLR4) activation leads to mitochondrial network remodeling and increased reactive oxygen species, stimulating inflammatory pathways and exacerbating lung injury during sepsis. The research will focus on defining the molecular mechanisms underlying TLR4-mediated mitochondrial fission and its impact on NF-κB signaling and the NLRP3 inflammasome. This work under the Cardiovascular Diseases Research program (CFDA 93.837) seeks to advance scientific understanding of mitochondrial dysfunction in acute lung injury and identify potential therapeutic targets.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $694.4k | 8/20/25 |