Project Grant R01HL183489
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $249,000 Project Grant to The Ohio State University on July 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports research investigating post-transcriptional mechanisms of direct cardiac reprogramming—specifically, how RNA-binding proteins and m6A (N6-methyladenosine) modifications regulate the conversion of cardiac fibroblasts into induced...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $811,885 to the J. David Gladstone Institutes under the Cardiovascular Diseases Research program (CFDA 93.837) on September 12, 2025. The award funds research to elucidate epigenomic mechanisms of cardiac fibrosis and heart failure pathogenesis, with a completion date of May 31, 2029. The research leverages novel genetic mouse models, advanced transcriptional and epigenomic...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $1,095,370 to the University of Colorado-Denver on August 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to support basic research into the epigenetic control of cardiac fibrosis. The project, titled "Hat-Dependent Control of Cardiac Fibrosis," investigates how histone acetyltransferases (HATs)—specifically P300 and CREB-binding protein (CBP)—regulate the...
- Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Washington University a $764,681 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of a multipotent cardiac fibroblast population in heart failure-related fibrosis and immune dysfunction. The research, spanning from May 1, 2026, through January 31, 2030, will deliver mechanistic discoveries and preclinical evidence regarding platelet-derived growth factor...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $231,552 Project Grant to the University of California, San Diego on September 16, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). This research project, titled "Tissue Elasticity and Viscosity Modulates Macrophage-Fibroblast Signaling in Cardiac Fibrosis," focuses on investigating the mechanisms underlying cardiac fibrosis through the study of interactions between...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Sanford Burnham Prebys Medical Discovery Institute a $1.6M Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective July 1, 2026, through March 31, 2028, to develop a single-construct gene therapy for enhanced cardiac repair. The project addresses cardiac fibrosis—a pathological feature common to multiple cardiovascular disease states that currently lacks effective antifibrotic treatment...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $799,256 to the University of California, San Diego on June 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The research project, "Cardiac Protection by Neuromodulation After Myocardial Infarction," extends through March 31, 2031, and investigates the mechanisms by which neuromodulation can mitigate adverse cardiac remodeling following...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Arkansas a $546,654 Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) effective May 1, 2026 through January 31, 2030 to develop computational and experimental platforms for predicting and controlling cardiac fibrosis in heart failure with reduced ejection fraction (HFrEF) patients. The project integrates systems mechanobiology modeling with patient-derived cardiac...
- Federal Project Grant Award Summary The Broad Institute of MIT and Harvard received a $173,825 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 1, 2026, through June 30, 2031. The grant funds functional genomics research to investigate gene regulatory networks in cardiac fibrosis, specifically addressing the transcriptional mechanisms that promote and maintain activated cardiac...
- Federal Project Grant Award Summary The University of California, San Diego received a $609,574 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 1, 2026, through March 31, 2030. This award funds basic research investigating the cellular and molecular mechanisms that regulate cardiac chamber morphology, specifically focusing on how cardiomyocytes acquire distinct shapes and organizational...
The National Heart, Lung, and Blood Institute (NHLBI) awarded $1,570,460 to the University of Cincinnati's Sponsored Research Services Division on July 6, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support research on cardiac reprogramming and fibrosis mitigation. The project, titled "Targeted Rewiring of a Fibrosis Driver to Enhance Cardiac Reprogramming," will deliver basic and translational research outcomes through May 31, 2028, focused on developing novel therapeutic approaches to prevent excessive cardiac fibrosis following myocardial infarction. The research employs CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) gene-editing technology and synthetic biology techniques to manipulate transforming growth factor beta (TGFβ) signaling pathways, aiming to convert cardiac fibroblasts into functional cardiomyocytes and thereby improve cardiac repair and reduce heart failure progression. The project will generate fundamental scientific knowledge regarding fibrosis mechanisms and cellular reprogramming efficiency, with potential applications for developing anti-fibrotic therapeutic interventions. Deliverables are expected to include peer-reviewed publications, validated CRISPR-based biodevices, experimental data on fibroblast-to-cardiomyocyte conversion efficacy, and mechanistic insights into TGFβ signaling in cardiac remodeling—advancing the state of cardiovascular disease research and contributing to the NHLBI's mission to prevent and treat heart and blood diseases.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.6m | 7/7/26 |