Project Grant R01HL178767
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $292,500 Project Grant to Sanford Burnham Prebys Medical Discovery Institute effective August 15, 2025, through July 31, 2027, under the Cardiovascular Diseases Research program (CFDA 93.837). This interdisciplinary research project aims to identify and characterize novel microproteins encoded by small open reading frames (SMORFs) that play critical roles in normal hematopoiesis and hematopoietic...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $811,885 to the J. David Gladstone Institutes under the Cardiovascular Diseases Research program (CFDA 93.837) on September 12, 2025. The award funds research to elucidate epigenomic mechanisms of cardiac fibrosis and heart failure pathogenesis, with a completion date of May 31, 2029. The research leverages novel genetic mouse models, advanced transcriptional and epigenomic...
- Federal Project Grant Award Summary The University of California, San Diego received a $1,519,594 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, through May 31, 2029. The award funds basic research investigating the biological mechanisms of the infarct borderzone—the transitional region between dead and viable cardiac tissue following myocardial infarction. The research will...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of California, San Diego a $1,507,470 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective August 1, 2025, through May 31, 2029, to investigate the gene regulatory mechanisms controlling cardiac myosin heavy chain (MYH) expression and isoform switching. The research will employ a multidisciplinary approach to examine cis-regulatory sequences and trans-acting factors that...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $231,552 Project Grant to the University of California, San Diego on September 16, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). This research project, titled "Tissue Elasticity and Viscosity Modulates Macrophage-Fibroblast Signaling in Cardiac Fibrosis," focuses on investigating the mechanisms underlying cardiac fibrosis through the study of interactions between...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded UC San Diego a $1,427,011 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective August 15, 2025, with completion scheduled for May 31, 2030. The project investigates major histocompatibility complex (MHC) gene editing strategies to prevent hematopoietic stem cell transplantation (HSCT) graft rejection. The research addresses a critical clinical challenge: while HSCT can cure numerous...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Broad Institute, Inc. a Project Grant totaling $173,825 under the Cardiovascular Diseases Research program (CFDA 93.837) for the period July 1, 2026 through June 30, 2031. The award funds functional genomics research to investigate gene regulatory networks in cardiac fibrosis, addressing a critical gap in understanding the transcriptional mechanisms that drive and maintain activated cardiac...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the Regents of the University of California, San Francisco a $556,295 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) effective August 1, 2025, with completion scheduled for May 31, 2030. This award supports research to advance understanding of cardiac pacemaking physiology and sinus node dysfunction (SND) through investigation of specialized pacemaker cell subpopulations. The...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Stanford University a Project Grant of $159,512 under the Cardiovascular Diseases Research program (CFDA 93.837) effective December 1, 2025, with completion targeted for May 1, 2026. This grant supports research into amelioration of cardiac fibrosis using diverse cell village human cardiac organoids. The project focuses on developing and validating therapeutic approaches to combat fibroblast activation, a...
- Federal Grant Award Summary The University of California, San Diego received a $799,256 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective June 5, 2026, with a completion date of March 31, 2031. This award supports integrated research investigating cardiac protection mechanisms through neuromodulation following myocardial infarction. The research deliverables encompass three primary investigative...
Sanford Burnham Prebys Medical Discovery Institute received a $1.60 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 1, 2026, with completion targeted for March 31, 2028. The award funds development of a single-construct gene therapy designed to enhance cardiac repair by simultaneously inducing overexpression of three cardiac reprogramming transcription factors (MEF2C, GATA4, and TBX5) while suppressing ATF7IP expression. This therapeutic approach aims to reprogram cardiac fibroblasts into functional cardiomyocyte-like cells more efficiently than current methods, thereby reducing scar tissue formation and improving heart function following myocardial infarction. The project addresses a critical unmet medical need in heart failure treatment. Cardiac fibrosis is a common pathological feature across multiple cardiovascular disease etiologies and contributes to both heart failure with preserved and reduced ejection fractions. By overcoming the technical barrier of low cardiac reprogramming efficiency—a key obstacle to clinical translation—this gene therapy approach has potential to provide a more effective treatment strategy for heart repair in patients with myocardial ischemia, infarction, and subsequent heart failure.Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.6m | 6/30/26 |