Project Grant R01HL183355
- Federal Grant Award Summary George Washington University received a $1,284,710 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) awarded September 1, 2025, with completion anticipated by May 31, 2029. The project deliverable is the development of a wireless, soft, implantable platform for in vivo cardiac calcium-voltage mapping and cardiac pacing to investigate the mechanisms of cardiac arrhythmias. The...
- The National Science Foundation awarded a $450,000 Project Grant to the George Washington University under the Engineering federal grant program (CFDA 47.041) to develop scalable heart-on-a-chip platforms. Over a three-year period from April 2022 through March 2025, the University will create automated systems integrating human heart slice culture components with sensor and actuator arrays. This will enable continuous on-chip multiparametric analysis of human cardiac physiology at the cellular...
- Federal Grant Award Summary Aventusoft LLC received a $500,000 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 15, 2025, with completion targeted for June 30, 2026. The award supports late-stage development and commercialization readiness activities for HATS-OFF (HemotTag Assessment for Short-Term Outcomes of Heart Failure), a non-invasive hemodynamic monitoring device designed to detect heart...
- Federal Project Grant Award Summary Northwestern University received a $696,259 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 1, 2026, with completion targeted for April 30, 2031. The grant supports research integrating flexible electronics and optogenetics to enable real-time arrhythmic profiling of engineered heart tissues (EHTs). The project addresses limitations in current arrhythmia...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Washington University a Project Grant of $764,681 under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 1, 2026 through January 31, 2030. This award funds mechanistic research investigating cardiac fibroblast biology and fibrotic responses in heart failure. The research deliverables include comprehensive characterization of a novel stem cell antigen-1-expressing cardiac...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $811,885 to the J. David Gladstone Institutes under the Cardiovascular Diseases Research program (CFDA 93.837) on September 12, 2025. The award funds research to elucidate epigenomic mechanisms of cardiac fibrosis and heart failure pathogenesis, with a completion date of May 31, 2029. The research leverages novel genetic mouse models, advanced transcriptional and epigenomic...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $775,114 to the Research Institute at Nationwide Children's Hospital on June 12, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). This Project Grant supports preclinical evaluation of a tissue-engineered vascular graft (TEVG) designed for use in congenital heart surgery. The research aims to advance treatment outcomes for children with complex cardiac anomalies by developing...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Virginia a $1,423,306 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) for a project titled "Modeling Intra- and Inter-Cellular Networks for TRPC6-Dependent Cardiac Fibrosis." The award was obligated on August 15, 2025, with a completion date of April 30, 2029. The research addresses cardiac fibrosis—a major complication of myocardial infarction...
- Federal Grant Award Summary Filamentech, Inc. received a $297,720 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 15, 2025, with completion scheduled for July 14, 2026. The award supports the development and validation of MUSICO (Muscle Simulation Code), an in silico platform designed to predict the effects of disease and drug effectiveness in hypertrophic cardiomyopathy (HCM) and dilated...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded The Johns Hopkins University a $426,250 Project Grant (Award Date: April 1, 2026; Completion: March 31, 2028) to develop cardiac organoids with deliberate cellular heterogeneity for modeling sinus node dysfunction (SND). The project will deliver a human-derived induced pluripotent stem cell (iPSC)-based cardiac pacemaker organoid platform...
The National Heart, Lung, and Blood Institute (NHLBI) awarded George Washington University $738,027 on June 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop an optoelectronics integrated multimodal heart tissue platform for cardiac physiology research and therapeutic screening. The project, with completion targeted for February 28, 2030, will deliver a high-throughput hybrid heart tissue system that integrates microfluidic tissue culture chambers, optical microscopy, multielectrode arrays, and control electronics into a compact chip-based platform. This integrated system will enable chronic culture of human heart tissue slices and facilitate real-time, multiparametric online monitoring of cardiac properties in health, disease, and treatment conditions. The platform addresses critical limitations in conventional heart-on-chip systems by supporting chronic investigations without reliance on off-chip analysis methods, enabling synergistic probing of multiple cardiac parameters simultaneously, and incorporating electrical stimulation capabilities to maintain tissue function and evaluate frequency-dependent drug responses. The resulting tools and research insights will advance the field's understanding of human heart pathophysiology, disease mechanisms, and drug efficacy and toxicity profiles, providing capabilities that currently lie outside the scope of existing cardiac research instruments.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $738.0k | 6/8/26 |