Project Grant R01HL183128
- Federal Project Grant Award Summary The University of California, San Diego received a $1,519,594 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025 through May 31, 2029. The award supports fundamental research to advance understanding of biological mechanisms in the infarct borderzone—the critical region between dead and healthy heart tissue following myocardial infarction. This...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the Regents of the University of California, San Francisco a $556,295 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) effective August 1, 2025, with completion scheduled for May 31, 2030. This award supports research to advance understanding of cardiac pacemaking physiology and sinus node dysfunction (SND) through investigation of specialized pacemaker cell subpopulations. The...
- Federal Project Grant Award Summary The University of California, San Diego received a $609,574 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 1, 2026, with a completion date of March 31, 2030. The grant funds basic research investigating the cellular and molecular mechanisms that regulate cardiac chamber morphology, specifically how cardiomyocytes acquire distinct shapes and organizational...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $429,000 Project Grant to The Regents of the University of Colorado (University of Colorado-Denver) under the Cardiovascular Diseases Research program (CFDA 93.837) for a two-year project period (September 1, 2025 – August 31, 2027). The award supports research investigating the impact of selective vagal neuromodulation on heart failure indices. The primary deliverables include preclinical...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of California, Irvine a Project Grant of $711,796 under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 1, 2026 through April 30, 2030. The award funds development of a nanomaterial-engineered proteomic (NANOPRO) platform designed to map protein composition across distinct curved membrane structures in cardiomyocytes—specifically caveolae, clathrin-coated pits,...
- Federal Grant Award Summary The University of California, San Diego received a $3,008,247 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with completion targeted for August 31, 2029. This research grant supports investigation of cell-type specific mechanisms underlying mitral valve prolapse (MVP), one of the most prevalent valvular heart diseases affecting 2-3% of the general...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $231,552 Project Grant to the University of California, San Diego on September 16, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). This research project, titled "Tissue Elasticity and Viscosity Modulates Macrophage-Fibroblast Signaling in Cardiac Fibrosis," focuses on investigating the mechanisms underlying cardiac fibrosis through the study of interactions between...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $498,000 to the University of California, Irvine under the Cardiovascular Diseases Research program (CFDA 93.837) on July 21, 2025, with a completion date of June 30, 2028. This project grant funds research to identify novel epigenetic regulators of lymphocyte development, specifically focusing on T cell development and function. The research addresses a critical gap in understanding epigenetic...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Central Florida Board of Trustees a $726,035 Project Grant on September 12, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct comprehensive mapping of vagal and spinal afferent nerve innervation in rat and human hearts in both healthy and diseased states. The five-year project, scheduled for completion by June 30, 2030, will identify and characterize cardiac...
- Federal Project Grant Award Summary The University of California, San Francisco received a $169,120 Project Grant award dated July 28, 2025, from the National Heart, Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to fund research investigating the role of SYNE1-GIANT in atrial cardiomyopathy. The research project, which extends through March 31, 2030, addresses the mechanisms underlying atrial fibrillation (AF) and sinus node dysfunction (SND)—the...
Grant Award Summary The University of California, San Diego received a $799,256 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 5, 2026, with completion targeted for March 31, 2031. The award funds basic research investigating cardiac protection through neuromodulation following myocardial infarction. The research employs an integrated cardiac-neuro-immune approach examining three key neurobiological hubs: transient receptor potential vanilloid 1 (TRPV1) vagal sensory neurons, hypothalamic angiotensin II receptor type 1 (AT1AR) neurons, and interleukin-1 beta (IL1B) signaling in the superior cervical ganglia to understand how coordinated interventions at these neural nodes can mitigate pathological cardiac remodeling and improve outcomes following heart attack. The deliverables include mechanistic characterization of how TRPV1 sensory neurons sense and modulate ischemic injury through viral tracing and genetic profiling; functional mapping of hypothalamic circuit contributions to myocardial infarction outcomes using chemogenetic modulation combined with real-time echocardiography and electrophysiological monitoring; and investigation of whether IL1B blockade in the superior cervical ganglia disrupts neuroinflammation and sympathetic hyperactivation to prevent adverse cardiac remodeling. Advanced molecular techniques including single-nucleus RNA sequencing and spatial transcriptomics will characterize cellular responses across ischemic, border, and remote cardiac zones, generating fundamental knowledge to support development of neuromodulation-based therapeutics for post-infarction heart failure prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $799.3k | 6/9/26 |