Project Grant R01HL182839
- The National Heart, Lung, and Blood Institute, part of the Department of Health and Human Services, awarded $1,619,582 to the University of Virginia on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the cardio-splenic axis in acute myocardial infarction and post-MI heart failure. The project examines the immunopathological mechanisms by which plasmacytoid dendritic cells orchestrate post-MI inflammation and cardiac dysfunction. The research team...
- The National Heart, Lung, and Blood Institute awarded the University of Virginia $776,745 on August 17, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to define and target DELE1-mediated mitochondrial stress signaling in cardiomyopathy. The research addresses how mitochondrial dysfunction drives cardiovascular disease, including heart failure and ischemic injury, by characterizing the molecular mechanisms through which DELE1 acts as a mitochondrial stress sensor to...
- The National Heart, Lung, and Blood Institute awarded $1.559 million to the University of Pittsburgh on July 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to validate chemokine-like receptor 1 (CMKLR1)-targeted positron emission tomography as a noninvasive imaging tool for monitoring myocardial inflammation and predicting post-myocardial infarction heart failure risk. The research addresses a clinical gap in identifying patients with sustained macrophage-driven...
- The National Heart, Lung, and Blood Institute awarded the University of Virginia $760,465 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop deep learning methods that advance cardiac magnetic resonance strain imaging for personalized cardiac resynchronization therapy treatment planning. The award funds development of deep strain networks to rapidly and accurately predict myocardial displacements from cardiac magnetic resonance imaging, addressing...
- The National Heart, Lung, and Blood Institute awarded Yale University $445,000 under CFDA 93.837 (Cardiovascular Diseases Research) on August 1, 2026, to develop deuterium metabolic imaging (DMI) as a non-invasive diagnostic tool for hibernating myocardium in coronary artery disease patients. The award is classified as a Project Grant under NIH assistance type R21HL184055. The research addresses a clinical gap: roughly 4 million Americans with heart failure stemming from coronary artery...
- This Project Grant from the National Heart, Lung and Blood Institute, part of the Department of Health and Human Services, was awarded under the Cardiovascular Diseases Research program (CFDA 93.837) to develop clinical software to support quantitative analysis and interpretation of myocardial contrast echocardiography (MCE) data. Narnar, LLC received $757,197 to create software modules that enhance MCE's ability to identify coronary microvascular dysfunction (MVD). The software will average...
- The National Heart, Lung, and Blood Institute awarded the University of Southern California $240,206 under the Cardiovascular Diseases Research program (CFDA 93.837) on August 1, 2026, to engineer therapeutically programmed monocytes that adaptively immunomodulate the post-infarction myocardial microenvironment toward cardiac repair and regeneration. The award funds development of smart monocytes using synnotch receptor circuits that detect inflammation and respond by secreting...
- The National Heart, Lung, and Blood Institute awarded Vanderbilt University Medical Center $174,621 on August 17, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop cardiac magnetic resonance imaging (CMR) techniques for monitoring congenital heart disease using ultra-low field (ULF) MRI systems. The recipient will adapt CMR to an inexpensive, unshielded, open-geometry ULF MRI system and apply machine learning techniques to mitigate hardware limitations and...
- The National Heart, Lung, and Blood Institute awarded New York University $737,762 on May 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate endothelial inflammation and its role in ischemia with nonobstructive coronary arteries (INOCA). The research examines coronary microvascular dysfunction as a key mechanism in INOCA, a chronic disorder characterized by angina, dyspnea, physical limitation, and impaired quality of life. The project directly harvests...
- The National Heart, Lung, and Blood Institute awarded the University of Virginia $248,999 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the molecular mechanisms regulating T-tubule structure in the mammalian heart during mechanical load conditions. The research will employ novel magnetorheological elastomer culture systems to subject isolated cardiomyocytes to pathological overload while comprehensively characterizing excitation-contraction...
The National Heart, Lung, and Blood Institute awarded the University of Virginia $802,973 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop rapid point-of-care molecular imaging of immune activation in acute coronary syndrome and acute myocarditis using targeted microbubble contrast agents. The project applies myocardial contrast echocardiography with phosphatidylserine-incorporating lipid microbubbles (MB-PS) to detect inflammatory activation from recent but resolved ischemia. Aim 1 tests whether bedside MCE molecular imaging with MB-PS can enable rapid diagnosis or exclusion of acute coronary syndrome in the emergency department by imaging ischemic memory—detecting regions of recent ischemia—in patients with possible or suspected ACS. First-in-human studies have already validated this approach in patients with known high-risk ACS after percutaneous coronary intervention. Aim 2 addresses gaps in rapid diagnosis of acute myocarditis. The work translates a preclinical construct validated in models of myocardial inflammation into human clinical application, leveraging the intravascular confinement of microbubbles to characterize events at the endothelial-blood pool interface where complement-mediated and PS receptor-specific attachment to activated leukocytes and endothelial cells occurs. Performance occurs in Charlottesville, Virginia. The period of performance runs from August 1, 2026, through May 31, 2030. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $803.0k | 7/31/26 |