Project Grant R01HL176909
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded New York University's Long Island School of Medicine a Project Grant totaling $2,728,306 under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on reducing plasma cholesterol and atherosclerosis using microRNA-30C analog C2. The research initiative, which commenced on September 24, 2025, and extends through August 31, 2027, focuses on developing and validating a novel synthetic...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Feinstein Institutes for Medical Research a $586,866 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective May 15, 2026, through February 28, 2030. The research investigates the critical role of B-1A cells, an immunoregulatory B cell subset, in mitigating acute lung injury (ALI) and acute respiratory distress syndrome—life-threatening inflammatory conditions frequently caused by sepsis...
- Federal Grant Award Summary New York University School of Medicine received a $165,672 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with completion targeted for August 31, 2030. The award supports research aimed at increasing heart transplant (HT) donor utilization in the United States by addressing two primary research objectives. First, the project will investigate the...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Columbia University's Health Sciences Division a $1,151,500 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) to investigate novel concepts in macrophage biology and their roles in atherosclerotic cardiovascular disease and cardiometabolic disease. The award, obligated on March 9, 2026, with a completion date of February 28, 2033, supports a comprehensive research program examining the...
- Federal Grant Award Summary New York University School of Medicine is conducting research under a $819,532 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award, effective June 25, 2025, with an ultimate completion date of March 31, 2030, funds an investigation into HLA eplet mismatches (EMM) as a biomarker for immunologic risk in heart transplant recipients. The research addresses a critical...
- Federal Grant Award Summary New York University School of Medicine received a $762,747 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 22, 2025, with completion targeted for May 31, 2030. The project delivers research and development of engagement protocols designed to facilitate communication and ethical conduct with donor family members and healthcare staff participating in...
- Federal Grant Award Summary New York University received a $272,226 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025 through August 31, 2027. The grant funds a secondary analysis research project that will deliver empirical evidence on how clinician and scheduling characteristics within intensive care unit (ICU) interprofessional teams impact patient outcomes for...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $814,387 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) under the Cardiovascular Diseases Research program (CFDA 93.837). The award, effective August 1, 2025 through April 30, 2029, funds research investigating lung vascular Group 3 Innate Lymphoid Cell (ILC3) subpopulations and their roles in antibacterial immunity and vascular regeneration. The...
- Federal Project Grant Award Summary Weill Medical College of Cornell University received a $109,076.00 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded March 3, 2026, with completion targeted for September 14, 2029. This award supports the development and application of single-cell total RNA sequencing (scTRS) methodology to identify and characterize the role of noncoding RNAs in normal...
- Federal Project Grant Award Summary Yale University received a $958,850 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with a completion date of May 31, 2029. This research project focuses on investigating interleukin-1 (IL-1) signaling mechanisms in critically ill children with bronchiolitis to identify disease severity markers and develop therapeutic interventions. The...
New York University School of Medicine received a $737,762 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 15, 2026, with a completion date of February 28, 2031. The award supports a comprehensive research initiative investigating endothelial inflammation and health status in patients with Ischemia and Nonobstructive Coronary Arteries (INOCA). The research encompasses three complementary study components: direct harvesting and transcriptional analysis of coronary artery endothelial cells from 125 patients undergoing invasive coronary function testing to evaluate inflammatory signatures in individuals with and without coronary microvascular dysfunction (CMD); assessment of transcriptional profiles in brachial vein endothelial cells to establish systemic biomarkers of CMD; and characterization of relationships between endothelial transcriptional signatures and patient-reported outcomes including symptoms, quality of life, functional capacity, and physical activity at baseline and one-year follow-up. The research deliverables will generate novel scientific findings regarding inflammation-mediated mechanisms of coronary microvascular dysfunction, establish whether endothelial abnormalities are systemic versus localized to coronary vasculature, and identify potential biomarkers and therapeutic targets to reduce cardiovascular morbidity and improve health outcomes in the INOCA patient population. Results will contribute to advancing understanding of disease pathogenesis and may inform development of targeted interventions to address symptom variability and improve clinical management of this chronic cardiovascular disorder.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $737.8k | 5/1/26 |