Project Grant R01HL182101
- The University of Maryland, College Park will receive $536,244 from the National Science Foundation under the Engineering federal grant program (CFDA 47.041) for a project grant titled "Engineering Host-Pathogen Interactions to Understand Influenza A Infection." The funding, awarded on October 1, 2022 and set to be completed by September 30, 2025, will support research examining the physical and biochemical factors that influence how influenza A virus penetrates and overcomes the...
- The University of Maryland, College Park received a $423,803 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct research on defining the STING protein interactions required for rhinovirus replication. The project aims to investigate how the STING protein traffics to viral replication organelles and influences lipid metabolism pathways to promote rhinovirus infection. The award period is from July 15,...
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $702,308 project grant to the University of Colorado-Denver for a study titled "Function and Regulation of Airway Mucin Glycosylation". The project, with a performance period from September 1, 2025 to June 30, 2029, aims to investigate the role of mucin glycosylation, specifically the enzyme fucosyltransferase 2 (FUT2), in regulating mucus...
- This $1,831,848 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate how early-life disruptions to gut microbiota colonization can remodel the development of lung immune and epithelial cells, contributing to chronic respiratory diseases. The research aims to identify the critical window and key microbial taxa required for establishing long-term lung homeostasis. Preliminary data indicates that...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is for $249,000.00 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) from August 1, 2025 to July 31, 2028. The objective of this research is to improve the mechanistic understanding of mucin biology, particularly the polymerization and trafficking mechanisms of mucin from the endoplasmic reticulum to the Golgi. The research aims to employ mouse...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $233,250 to the University of North Carolina at Chapel Hill (UNC-CH) to investigate the role of lipid metabolism in lung macrophage activity and phenotypes during acute lung injury. The project aims to understand how changes in lipid metabolism alter the function of lung macrophages during influenza A virus infection, which can lead to lung inflammation...
- The University of Maryland, Baltimore received a $678,445 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to study a novel regulator of cardiomyocyte function and homeostasis. The research aims to determine the mechanisms by which the C5ORF51 (C5X) protein modulates transcription in cardiomyocytes and investigate its role in adult cardiomyocyte proliferation and maturation. This innovative research has the potential to uncover...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $759,983.00 to the University of North Carolina at Chapel Hill to conduct research on the role of neutrophils in lung infections and acute lung injury. The study aims to examine changes in neutrophil transcriptomes and function during Streptococcus pneumoniae pneumonia, with the goal of improving understanding of the lung's immune response and potential...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $754,729 to the University of Pittsburgh to investigate the mechanisms by which respiratory viral infections, including COVID-19, can lead to persistent lung inflammation and damage. The research aims to understand how viral antigen persistence in pulmonary endothelial cells drives chronic activation of CD8+ T cells, leading to long-term pulmonary sequelae. The...
- The Washington University was awarded a $761,782 Project Grant from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) on September 1, 2025, with a completion date of July 31, 2029. The grant supports comprehensive research to investigate the cellular processes resulting in acquired airway ciliopathies, which are characterized by loss of cilia maintenance and impaired airway clearance observed in lung diseases such as asthma and COPD. Key objectives...
The University of Maryland, College Park received a $711,144 project grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on the role of glycan-mediated interactions in the mucus barrier's ability to neutralize diverse respiratory viruses, including influenza A, rhinovirus, and respiratory syncytial virus. The project aims to determine how mucin-associated glycans dictate the structural properties and mucociliary clearance of the lung's mucus barrier, and how specific mucins and glycans impact the trapping and infection dynamics of various respiratory viruses. The research will utilize genetically-modified human airway epithelium models and is expected to be completed by June 30, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $711.1k | 8/21/25 |