Project Grant R00HL165072
Award Date 8/1/25
Completion Date 7/31/28
Dollars Obligated $249K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Kansas City, KS 66160, USA
Similar Awards
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $702,308 project grant to the University of Colorado-Denver for a study titled "Function and Regulation of Airway Mucin Glycosylation". The project, with a performance period from September 1, 2025 to June 30, 2029, aims to investigate the role of mucin glycosylation, specifically the enzyme fucosyltransferase 2 (FUT2), in regulating mucus...
- This federal Project Grant award of $718,002 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to validate and expand on the discovery of unique inflammatory and hypoinflammatory endotypes within idiopathic pulmonary fibrosis (IPF) lung tissue and microenvironment. The research, conducted by the University of Kansas Medical Center Research Institute, Inc. (KUMCRI), will perform proteomic analysis on IPF bronchoalveolar lavage fluid and lung...
- The University of Maryland, College Park received a $711,144 project grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on the role of glycan-mediated interactions in the mucus barrier's ability to neutralize diverse respiratory viruses, including influenza A, rhinovirus, and respiratory syncytial virus. The project aims to determine how mucin-associated glycans dictate the structural properties and mucociliary clearance of...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $161,890 to the University of Washington (UW) to support research on the role of alveolar macrophages in the host response to gram-negative bacterial pulmonary infections, such as those caused by Burkholderia pseudomallei. The research aims to elucidate the significance of alveolar macrophages as an intracellular replication niche for Burkholderia species, as well...
- This Project Grant award of $629,319.00 from the National Heart Lung and Blood Institute (CFDA #93.837 Cardiovascular Diseases Research) supports research by Emory University to investigate cellular mechanisms for overcoming refractory cystic fibrosis defects. The research aims to identify ribosomal proteins that can partially rescue the synthesis and assembly of cystic fibrosis transmembrane conductance regulator (CFTR) protein variants with premature termination codons, which are associated...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $233,250 to the University of North Carolina at Chapel Hill (UNC-CH) to investigate the role of lipid metabolism in lung macrophage activity and phenotypes during acute lung injury. The project aims to understand how changes in lipid metabolism alter the function of lung macrophages during influenza A virus infection, which can lead to lung inflammation...
- This federal Project Grant award, totaling $756,875.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Cincinnati. The award supports research to investigate the fundamental mechanisms by which neutrophil extracellular traps (NETs) contribute to airway damage and infection in mucoobstructive lung diseases, such as cystic fibrosis. Key research aims include examining how NET-mediated...
- This federal Project Grant award of $551,863 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research on how prostaglandin E2 (PGE2) regulates airway epithelial cells to balance liquid absorption and secretion. The research aims to establish new regulatory mechanisms controlling airway surface liquid volume, with the goal of identifying novel therapeutic targets for pulmonary diseases. The project is conducted by researchers at the...
- The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) was awarded a $774,997 project grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to conduct research on the contribution of medullary pre-sympathetic neurons to the progression of breathing disorders and autonomic dysfunction in heart failure with preserved ejection fraction (HFPEF). The project aims to provide in-vivo and in-vitro neuronal activity mapping of the...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,061,189 to the Regents of the University of Michigan to conduct research on immune crosstalk in lung injury and fibrosis. The key objectives are to study epithelial cell regulation of fibrosis and its interaction with myeloid cells, uncover mechanisms for impaired innate immunity against gram-positive infections in fibrosis, test delivery of targeted therapeutics...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is for $249,000.00 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) from August 1, 2025 to July 31, 2028. The objective of this research is to improve the mechanistic understanding of mucin biology, particularly the polymerization and trafficking mechanisms of mucin from the endoplasmic reticulum to the Golgi. The research aims to employ mouse models and knockdown approaches in human cell lines and primary cultures to elucidate the role of key molecular components in mucin assembly and transport, which is critical for improving treatments for muco-obstructive respiratory diseases.
Generated 10/21/25, 5:31 AM
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 7/30/25 |