Project Grant R01HL181939
- The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), awarded a $766,920 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program. The grant, effective May 15, 2025 through February 28, 2029, will support research by Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking skeletal muscle health and vascular function in obesity. The research aims to...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,092,000 to The Medical College of Wisconsin, Inc. to conduct research on the intersection of the PPARG-RHOBTB1-CULLIN-3 pathway and the renin-angiotensin system and their impact on blood pressure, vascular function, and arterial stiffness. The research aims to advance understanding of the regulatory circuits governing vascular function and arterial structure,...
- This Project Grant award, totaling $786,060.00, was provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The grant aims to investigate how hypertension induces "trained immunity" in myeloid cells, which may drive the development of atherosclerosis even after lowering cholesterol and blood pressure. Key research activities include: Transplanting hematopoietic stem and progenitor cells from hypertensive mice into...
- The Project Grant award of $2,868,266.00 from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), supports research at Temple University to investigate the role of the vascular enzyme pyruvate kinase M2 (PKM2) in mediating hypertension and vascular remodeling. The project aims to explore how angiotensin II-induced activation of PKM2 in vascular smooth muscle cells contributes to hypertension and remodeling of both conductance and...
- This federal Project Grant award for $732,261 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to identify central obesity genes and validate their function using in vitro and in vivo models. The project aims to leverage large-scale, multi-ethnic genomic and multi-omic data from nine longitudinal studies in the NHLBI Trans-Omics for Precision Medicine (TOPMed) program to pinpoint target genes that...
- This federal Project Grant award, valued at $518,613.00 and granted by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research to define the molecular basis of thrombospondin-1-induced fibro-fatty diaphragm remodeling, a driver of obesity-associated respiratory dysfunction. The research, conducted by the Regents of the University of Michigan, aims to investigate the role of the matricellular protein thrombospondin-1 in promoting...
- This Project Grant award, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research on how tissue elasticity and viscosity modulate the signaling between macrophages and fibroblasts in cardiac fibrosis. The $231,552 award, granted to the University of California, San Diego, will fund research to investigate the effects of mechanical stimuli on macrophage-fibroblast interactions and explore the role of a changing mechanical...
- This Project Grant award of $618,450.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to identify key regulators of vascular homeostasis and understand how they maintain normal vascular function. The principal investigators at the Medical College of Wisconsin are focusing on understanding the role of the RNA-binding protein PABPC1 in suppressing endothelial cell activation and inflammation to prevent the loss of vascular...
- This $734,722 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a randomized controlled clinical trial to assess the impact of disclosing systolic blood pressure polygenic risk scores on blood pressure control, healthy lifestyle adherence, and cardiometabolic health among 300 hypertensive adults aged 18-55 in the United States. The study aims to evaluate whether providing individuals with information about their...
- This $385,381 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of dynamic biological hydrogels to modulate cardiac remodeling following myocardial infarction. The primary goals are to: 1) Improve the mechanical stability and stiffness of cardiac extracellular matrix hydrogels compared to existing therapies, and 2) Leverage changes in extracellular matrix composition to promote a more regenerative...
This $685,654 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the role of tissue transglutaminase (TG2) in arterial stiffening and hypertension associated with obesity. The central hypothesis is that obesity-induced upregulation of TG2 in vascular smooth muscle cells contributes to increased arterial collagen crosslinking, actin polymerization, and myogenic tone, leading to vascular stiffening and hypertension. The 4-year project will utilize genetic manipulations and a novel TG2 inhibitor in cell cultures, animal models, and an obese-hypertensive pig model to elucidate the mechanisms by which TG2 promotes obesity-related vascular dysfunction and test the therapeutic potential of TG2 inhibition. This innovative research aims to improve understanding of the underlying causes of obesity-associated cardiovascular disease and develop new treatment approaches.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $685.7k | 8/26/25 |