Project Grant R01HL181539
- This federal Project Grant award of $740,037, funded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research on the regulation of angiogenesis (blood vessel formation) by cardiac fibroblasts following myocardial infarction. The key objectives are to investigate the temporal and spatial expression of pro- and anti-angiogenic factors secreted by cardiac fibroblasts to support cardiac repair and increase vascular...
- The University of California, San Diego (UCSD) was awarded a $788,513 project grant by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to study the mechanisms underlying the maintenance of cardiac chamber identity in zebrafish. The research aims to elucidate the genetic pathways that reinforce ventricular cardiomyocyte identity, as ventricular myocardium harbors considerable plasticity and can transform to acquire atrial traits under certain...
- This $761,152 project grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of California, San Diego (UCSD) to investigate the gene regulatory mechanisms controlling the expression of cardiac myosin heavy chain proteins. The goal is to understand how shifts in the ratio of the MYH6 and MYH7 isoforms impact cardiac contractility, which is critical for heart function under both normal and disease...
- This Project Grant award, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research on how tissue elasticity and viscosity modulate the signaling between macrophages and fibroblasts in cardiac fibrosis. The $231,552 award, granted to the University of California, San Diego, will fund research to investigate the effects of mechanical stimuli on macrophage-fibroblast interactions and explore the role of a changing mechanical...
- This federal Project Grant award of $758,862.00 was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Yale University. The award supports research aimed at preventing cardiac remodeling and progressive heart failure following myocardial infarction (MI). Key objectives include developing a percutaneous, image-guided approach to deliver hydrogels of varying stiffness to the infarcted and peri-infarcted myocardium. This is intended to...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $536,468 to the University of California, San Diego (UC San Diego) to conduct research on protein aggregation in hematopoietic stem cells (HSCs). The project aims to investigate how HSCs, which regenerate blood and immune cells, preferentially traffic misfolded proteins to aggresomes to maintain fitness and self-renewal, and how this process is impacted by...
- The University of California, Davis received a $400,417 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to conduct research on cardiac regenerative therapy using gene-edited stem cells. The goal is to improve transplantation outcomes and address the critical role of inflammation-induced cell death that impedes current cardiac stem cell therapies. The research aims to develop new treatments for end-stage heart failure, a...
- The federal Project Grant award, titled "Focal Myocardial Delivery of Small Molecule Nitroalkenes Using Ultrasound Targeted Microbubble Cavitation to Improve Ventricular Recovery Following Myocardial Infarction," was awarded by the National Heart Lung and Blood Institute under CFDA 93.837, the Cardiovascular Diseases Research program. The $720,676 award, with a start date of March 4, 2025 and an ultimate completion date of December 31, 2028, aims to develop a novel therapeutic strategy...
- This Project Grant award for $727,710.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to advance understanding of the mechanisms driving arrhythmogenic cardiomyopathy, a genetic heart disease that can cause sudden death in young people. The award supports research at the University of California, San Diego (UCSD) to develop preclinical mouse models exhibiting inflammation and T-cell mediated immune responses as key drivers of this...
- This $556,295 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to advance scientific understanding of cardiac pacemaking and sinus node dysfunction (SND) through research on "conditional pacemaker cells" within distinct specialized pacemaker cell subpopulations. The project will leverage advanced optical mapping technology to directly visualize pacemaking activities within these specialized cell...
This federal Project Grant award, valued at $765,288.00, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The funding supports research at the University of California, San Diego (UCSD) to investigate the biological mechanisms of the infarct borderzone - the complex and dynamic region between areas of cell death and normal tissue in the heart following a myocardial infarction. The research aims to advance understanding of how this borderzone region contributes to infarct expansion and pathological remodeling, and to develop therapeutic strategies to limit these processes and prevent the progression to heart failure. The project will run from August 1, 2025 through May 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $765.3k | 7/28/25 |