Project Grant R01HL181254
- This federal Project Grant award of $604,818.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research at the University of Mississippi Medical Center (UMMC) to investigate the role of non-alcoholic fatty liver disease (NAFLD) in the development of cardiovascular disease, independent of obesity and metabolic dysfunction. The research project aims to determine how NAFLD can contribute to the development of hypertension, cardiac...
- The University of Alabama at Birmingham (UAB) received a $637,732 project grant from the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on improving the cardiac microenvironment as a novel strategy against diabetic ischemic heart failure. The project aims to leverage insights from cellular secretome research to transform treatment strategies for diabetic ischemic heart failure. Specifically, the research will investigate how...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $771,750 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of California, Los Angeles (UCLA) to investigate the role of macrophages in regulating cardiac muscle metabolism after myocardial infarction. The project aims to shed novel insights into how macrophages recruited to the infarcted heart disrupt cardiac muscle metabolism and lead to decreased NAD pools, which play a critical...
- The University of Mississippi was awarded a $731,969 project grant from the National Institutes of Health National Institute of General Medical Sciences to investigate collective myocardial cell movement during heart tube formation. Under the Biomedical Research and Research Training program (CFDA 93.859), the University will undertake a multi-dimensional approach examining cardiac fusion at the tissue, molecular, cellular and biomechanical levels. Graduate and undergraduate students will test...
- The University of Louisville was awarded a $728,529 project grant by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant will fund research to investigate the relationship between the acute immune response and wound healing processes that occur following a myocardial infarction (MI). The project aims to characterize how "emergency granulopoiesis" - the acute increase in neutrophil production in response...
- This Project Grant award, valued at $1,088,500.00, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The University of Iowa. The award supports three independent research projects related to genetic and molecular mechanisms of heart disease. Project #1 aims to define microRNA (miR) targeting events and their biological relevance in the heart, as well as understand the clinical significance of single nucleotide polymorphisms (SNPs)...
- This Cooperative Agreement award, totaling $740,915, was granted by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The overall goal of the award is to elucidate novel mechanisms linking placental ischemia and maternal systemic, cerebral, and renal dysfunction in preeclampsia, and to identify potential therapeutic targets. The University of Mississippi Medical Center, the award recipient, has developed and...
- The University of Maryland, Baltimore received a $678,445 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to study a novel regulator of cardiomyocyte function and homeostasis. The research aims to determine the mechanisms by which the C5ORF51 (C5X) protein modulates transcription in cardiomyocytes and investigate its role in adult cardiomyocyte proliferation and maturation. This innovative research has the potential to uncover...
- The University of Alabama at Birmingham (UAB) was awarded a $539,342 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on the circadian mechanisms governing cardiac growth. The project aims to investigate how the cardiomyocyte circadian clock regulates cardiac processes, particularly the branched chain amino acid catabolism and mTOR activation during the active and sleep periods. This research seeks to advance...
- The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) was awarded a $774,997 project grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to conduct research on the contribution of medullary pre-sympathetic neurons to the progression of breathing disorders and autonomic dysfunction in heart failure with preserved ejection fraction (HFPEF). The project aims to provide in-vivo and in-vitro neuronal activity mapping of the...
The University of Mississippi Medical Center (UMMC) was awarded a $540,927 Project Grant from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports research investigating the activation of the brain melanocortin 4 receptor (MC4R) pathway and its effects on brown adipose tissue (BAT) activity to potentially mitigate ischemia/reperfusion injury and prevent heart failure following a myocardial infarction. Key objectives include evaluating whether central MC4R activation, through direct brain infusion of an MC4R agonist, can improve cardiac function and metabolism after ischemic injury by increasing BAT thermogenesis. The project aims to advance understanding of the brain-heart communication mechanisms and explore MC4R activation as a new therapeutic approach for treating ischemic heart disease. The grant was awarded on September 1, 2025, with a targeted completion date of June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $540.9k | 8/18/25 |