Project Grant R01HL180774
- Federal Project Grant Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the Regents of the University of Minnesota a $1.58 million Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) for the period June 1, 2026, through February 29, 2028. The award funds research into novel therapeutic approaches for chronic graft-versus-host disease (CGVHD), with a primary focus on limiting tissue fibrosis. The research employs state-of-the-art technologies and...
- Federal Grant Award Summary The Regents of the University of Minnesota received a $174,528 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025 through August 31, 2030. This award supports reverse translational research to identify novel treatment targets for atrial myopathy, a condition involving structural, mechanical, or electrophysiological changes in the atria that may...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $657,595 to the Regents of the University of Minnesota on June 22, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop novel statistical methods and computational tools for high-dimensional mediation analysis. This project grant, which will be completed by February 28, 2030, addresses a critical gap in understanding the molecular pathways linking cardiovascular disease (CVD)...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the Regents of the University of Minnesota $398,144 under the Biomedical Research and Research Training program (CFDA 93.859) for a project grant extending from April 1, 2026, through January 31, 2031. The award supports the development of immunocompetent tissue engineering systems designed to model, modulate, and treat inflammatory diseases. The research combines human pluripotent stem cell...
- Federal Project Grant Award Summary The University of Michigan's Regents, through its Office of Research and Sponsored Projects Division, received a $1.12 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) awarded June 15, 2026, with completion scheduled for March 31, 2030. The award funds basic biomedical research investigating compartmentalized G Protein-Coupled Receptor (GPCR) signaling in cardiac...
- Federal Project Grant Award Summary The University of Michigan, through its Office of Research and Sponsored Projects, received a $651,349 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with a completion date of May 31, 2029. This award funds research investigating stoichiometric, adhesion, and contractile deficits in desmoplakin cardiomyopathy, a condition caused by genetic...
- Summary of Federal Project Grant Award The National Heart, Lung, and Blood Institute (NHLBI) awarded the Regents of the University of Minnesota a Project Grant totaling $389,748 under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 15, 2025, with completion targeted for July 31, 2027. This award funds a proof-of-concept research initiative to evaluate carotid pulse arrival time (CPAT) as a potential non-invasive biomarker for monitoring ascending thoracic aortic...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Wisconsin–Madison a Project Grant totaling $639,822 under the Cardiovascular Diseases Research program (CFDA 93.837) on September 15, 2025, with a completion date of June 30, 2029. This research project investigates the role of neutral sphingomyelinase (NSMase), a membrane enzyme involved in sphingolipid metabolism, in cardiac mechanosensing and signal transduction. The research...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Johns Hopkins University a $379,509 Project Grant effective July 1, 2026 through June 30, 2030 under the Cardiovascular Diseases Research program (CFDA 93.837). The project delivers research and development of mesenchymal stem cell (MSC) therapies with enhanced immunosuppressive efficacy for treating graft-versus-host disease (GVHD). The primary deliverable is the identification and provision of...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Wisconsin–Madison a Project Grant totaling $747,262 (awarded June 1, 2026; completion February 28, 2030) under the Cardiovascular Diseases Research program (CFDA 93.837). This award funds research to define the multi-omics landscape of phospholamban-induced cardiomyopathy through advanced proteomic analysis. The project will deliver scientific products including proteoform characterization...
Federal Project Grant Award Summary The University of Minnesota's Regents, through its Office of Sponsored Projects Administration, received a $543,957 Project Grant award dated July 6, 2026, from the National Heart, Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds research spanning approximately four years through May 31, 2030, and is directed toward developing innovative in vitro cardiac tissue models and understanding the mechanisms driving cardiomyocyte maturation. The research deliverables focus on characterizing how extracellular matrix (ECM) proteins mediate mechanical signaling to enhance the functional maturity of human pluripotent stem cell-derived cardiomyocytes (HPSC-CMs). The project employs a novel human chambered cardiac muscle pump model (HCHAMP) that simulates native cardiac mechanical forces, incorporates cardiac fibroblasts to model ECM remodeling, and utilizes advanced computational modeling to refine stimulation parameters and analyze ECM composition. Specific technical products include a validated computational fluid-structure interaction model replicating physiologic cardiac pressure profiles, mechanistic characterization of ECM deposition and remodeling under dynamic volumetric loading, and optimized mechanical stimulation protocols to enhance tissue-scale maturation. These research outputs are intended to support broader applications in cardiac disease modeling, pharmaceutical drug testing, and regenerative medicine.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $544.0k | 7/3/26 |