Project Grant R01HL180397
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of California, Los Angeles a $1.56 million Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective July 15, 2026, with completion targeted for March 31, 2028. This award funds basic science research to elucidate the role of noncoding RNA—specifically long noncoding RNAs (lncRNAs) and micropeptides—in cardiovascular disease pathogenesis, with emphasis on lipid metabolism,...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Southern California a $790,498 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) beginning September 1, 2025, and extending through June 30, 2030. The grant supports basic research investigating the novel role of PCBP1 (poly(C) binding protein 1), an RNA-binding protein, and its splicing target AARS2 in regulating vascular endothelial growth factor (VEGF)...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $1,072,936 to the University of California, San Diego, effective September 15, 2025, through June 30, 2029, under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports fundamental research investigating protein aggregation mechanisms in hematopoietic stem cells (HSCs), with the primary deliverable being scientific research and discovery designed to advance...
- Federal Project Grant Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $736,089 Project Grant to the University of California, Los Angeles on August 15, 2025, to support research on NNMT (Nicotinamide N-Methyltransferase) Inhibition for Treating Heart Failure through the Cardiovascular Diseases Research program (CFDA 93.837). The project, which extends through May 31, 2029, investigates the novel mechanism by which NNMT induction contributes to NAD+ (nicotinamide adenine...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $650,028 Project Grant to the University of California, Los Angeles (UCLA) on September 9, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). This project, titled "Sex-Dependent Regulation of Cardiac cAMP, ECC, and Arrhythmia by Phosphodiesterases," will be conducted through May 31, 2029, at UCLA's Davis, California location. The research will investigate the...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $711,796 Project Grant to the University of California, Irvine, effective July 1, 2026, through April 30, 2030, under the Cardiovascular Diseases Research program (CFDA 93.837). The project will develop a nanomaterial-engineered proteomic (NANOPRO) platform designed to map curvature-dependent cardiac signaling by creating unbiased, 20-nanometer-resolution proteomic atlases of distinct membrane...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $1,567,702 to the University of California, Los Angeles, under the Cardiovascular Diseases Research program (CFDA 93.837) on July 15, 2026, with an ultimate completion date of June 30, 2028. This project grant funds research to define the mechanisms underlying cardioneural ablation (CNA)-associated ventricular arrhythmogenesis and to enable safer clinical application of CNA—an emerging...
- Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of California, Los Angeles a $741,473 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective June 15, 2026, with completion targeted for March 31, 2030. The research investigates the mechanisms underlying diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF), focusing on the interplay between nitric oxide synthases (NOS), cyclic nucleotide messengers...
- Federal Project Grant Award Summary Stanford University received $165,488 in funding from the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) beginning March 5, 2026, with completion expected by December 31, 2028. This Project Grant supports hypothesis-driven research investigating the role of the transcription factor TCF21 in adventitial fibroblasts and atherosclerosis development. The research deliverables include characterization of...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Alabama at Birmingham a Project Grant of $535,556 under the Cardiovascular Diseases Research program (CFDA 93.837) effective August 1, 2025, with completion targeted for May 31, 2030. This award supports research to elucidate the role of a novel mechanosensitive histone modification (H3T32 O-GlcNAc) in atherosclerosis pathogenesis. The research investigates how atheroprone shear stress...
The National Heart, Lung, and Blood Institute (NHLBI) awarded University of California, Los Angeles $1,574,590 under the Cardiovascular Diseases Research program (CFDA 93.837) on July 15, 2026, with a completion date of March 31, 2028. This Project Grant funds basic and translational research to elucidate the role of alternative polyadenylation (APA) in cardiovascular disease and lipid metabolism. The research integrates computational, molecular, cellular, and animal model approaches to investigate how gene variants influence transcript 3' untranslated region (3'UTR) length regulation and function, with specific focus on the TBL2 gene's role in serum triglyceride and lipoprotein metabolism using novel transcriptome-wide association study methodologies. The award supports a multi-aim research program designed to uncover previously unexplored pathways linking genetic variants to cardiovascular phenotypes through APA-mediated mechanisms. Deliverables include development and validation of computational pipelines for identifying APA-linked risk genes, characterization of hepatic TBL2 function and its 3'UTR length variation in lipid metabolism through experimental investigation, and generation of mechanistic insights that could inform future therapeutic strategies for cardiometabolic disease prevention and treatment. This work represents fundamental biomedical research aligned with NHLBI's mission to foster hypothesis-driven mechanistic research across the cardiovascular disease spectrum.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.6m | 7/7/26 |