Project Grant R01HL179211
- This federal Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of the protein TBC1D2B in the formation of new blood vessels after ischemic injury. The $720,526 award, with a project period from September 1, 2025 to June 30, 2029, aims to uncover the mechanisms underlying endothelial tube formation, which is crucial for the structural and functional...
- This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), is focused on investigating the role of Plasminogen Activator Inhibitor 1 (PAI1) as a potential therapeutic target for maternal endothelial dysfunction in preeclampsia. The $806,978 award, with a performance period from August 1, 2025 to June 30, 2030, will support research at Yale University to gain insights into maternal...
- This federal Project Grant award of $618,450.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research focused on identifying key regulators of vascular homeostasis and understanding how they maintain normal vascular function. The principal investigator will use a combination of in silico and in vitro screening approaches to identify the RNA-binding protein PABPC1 as a critical suppressor of endothelial cell activation, which can...
- This Project Grant award of $775,720.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research by Yale University to investigate the role of endothelial protocadherins in vascular development and disease. The key research objectives are to: 1) Determine the effects of knocking out the protocadherin gamma (PCDHG) cluster in endothelial cells or inhibiting the PCDHGA9 isoform in mouse models of vascular inflammation; 2) Elucidate the...
- This $429,000 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research to investigate the gene and environmental influences on placental angiogenesis and severe fetal growth restriction. The 2-year project, awarded to the University of Colorado-Denver, leverages induced pluripotent stem cell technology to study the development of placental vasculature and...
- This Project Grant award, valued at $790,498 and starting on September 1, 2025, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The award aims to research the novel role of the PCBP1 and AARS2 proteins in regulating vascular endothelial growth factor (VEGF) signaling, which is crucial for normal blood vessel development but also drives the progression of diseases like cancer and diabetic...
- This $151,040 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research into the effects of rare damaging mutations in TGFB latent complex proteins found in preeclamptic placentas. The project aims to investigate how these mutations impact TGF-beta signaling, extracellular matrix integrity, and the migration, invasion, and...
- This Project Grant award, valued at $636,982.00 and awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research to comprehensively investigate the proteolytic mechanisms that govern the regulation of Factor VIII (FVIII) before and after activation. The goal is to understand how proteolysis of FVIII or FVIII/von Willebrand Factor (VWF) modulates plasma FVIII concentration, as well as the physiological relevance of activated protein...
- This Project Grant award of $723,084 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the PAR1/IL-17 signal axis and its role in propagating abnormal chronic thrombus development and pulmonary vascular remodeling in Chronic Thromboembolic Pulmonary Hypertension (CTEPH). The research is being conducted by the University of Colorado-Denver, a prominent public research university, with the goal of advancing...
- This federal Project Grant award of $744,692.00, awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) on August 15, 2025, supports research into the mechanical regulation of cardiac growth and remodeling by VCAN-GPR126 signaling. The research aims to test the hypothesis that VCAN-GPR126 signaling is stimulated by mechanical forces during both cardiac development and postnatal remodeling. Key objectives include using conditional and mutant...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $722,824 to The Trustees of the University of Pennsylvania to investigate the role of the VEGFR1 protein and thrombin signaling in the growth and development of the placental vasculature. The research aims to advance the understanding of how the placenta, a critical organ for fetal development, creates its complex vascular network and grows in concert with the embryo. By leveraging genetic mouse models and analyzing molecular mechanisms, the project seeks to elucidate the agonist and antagonist functions of VEGFR1 and the regulatory effects of thrombin signaling on placental vascular growth. This research has implications for understanding and addressing pregnancy-related complications such as preeclampsia. The award period runs from August 2025 through April 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $722.8k | 8/21/25 |